EFFICACY OF EPIDURAL POLYETHYLENE GLYCOL IN SPINAL CORD INJURED DOGS TREATED WITH INTRAVENOUS METHYL PREDNISOLONE SODIUM SUCCINATE
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Date
2017
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES-MANNUTHY,THRISSUR
Abstract
The study was conducted in sixteen dogs with clinical signs of spinal cord injury (SCI). The dogs were randomly divided into two groups, Group I and Group II. Animals of Group I were subjected to single intravenous administration of methyl prednisolone sodium succinate (30 mg/kg body weight) on first day of presentation, while in Group II animals, methyl prednisolone sodium succinate at the rate of 30 mg/kg body weight intravenously and 10% solution of Polyethylene glycol (4000 Da) at the rate of 0.2 ml/kg body weight epidurally were administered. In both groups, the treatment was followed by oral administration of prednisolone at the rate of 1mg/kg body weight at divided and tapering doses for next 10 days. All dogs were given supportive therapy with neurotrophic vitamin and analgesic for 30 days. Clinical and neurological changes were evaluated at weekly interval to assess the effect of the treatment. In the study, the incidence of SCI was found more in non descript dogs (31.25%) followed by Dachshunds (25%); 56% of affected dogs were female and, 56.5% dogs belonged to age group of three to six years. The aetiology was unknown in most of the cases (56.25%) and trauma due to road traffic accidents was reported mainly among the rest. Neurological, radiographic and epidurographic examination suggested that, the SCI was at thoracolumbar region in majority of the cases. Haematological and serum biochemical parameters were not affected by spinal cord injury or the treatment adopted, except for a rise in C-reactive protein, alkaline phosphatase and lactate dehydrogenase. Among Group I animals, 62.5% had recovered from the condition and 87.5% in Group II by the end of eighth week. The recovery was found to be earlier among the animals of Group II. It was concluded that single administration of 10% polyethylene glycol (0.2ml/kg body weight) epidurally along with methyl prednisolone sodium succinate (30mg/kg body weight) intravenously was more effective in the treatment of spinal cord injuries in dogs
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