EVALUATION OF OXIDATIVE STRESS IN ANAEMIA ASSOCIATED WITH HAEMOPROTOZOAN INFECTIONS IN DOGS
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Date
2022-08-10
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES, POOKODE, WAYANAD, KERALA VETERINARY AND ANIMAL SCIENCES UNIVERSITY
Abstract
In order to assess the oxidative stress in anaemic dogs with haemoprotozoan infections, a total of 12 blood samples from anaemic dogs (Hb ≤ 12 g/dL) confirmed positive for Babesia gibsoni and B. canis were collected. The samples were subjected to a complete blood count to assess the RBC count, WBC count, haemoglobin, haematocrit, MCV and MCHC. Oxidative stress was assessed by measuring RBC activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and serum total antioxidant capacity (TAC). Amongst the haematological parameters, the RBC count, WBC count, haemoglobin and haematocrit were all significantly reduced in the infected dogs. All the antioxidant parameters viz. RBC SOD and GPx activities, and serum TAC were found to be significantly increased in the infected dogs. All except one of the findings of this study corroborate with the findings of earlier studies, the exception being the RBC GPx activity. The hallmark of this study is the finding of the RBC GPx activity being elevated in the infected dogs. Significantly elevated GPx activity in dogs in relation to being cytologically and clinically positive for haemoprotozoans is a unique finding that has not been reported till date.