IMMUNOTOXICOLOGICAL STUDIES OF SUBACUTE PERMETHRIN EXPOSURE AND ITS AMELIORATING POTENTIAL BY CURCUMA LONGA IN MICE
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Date
2007
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Anand Agricultural University, Anand
Abstract
Present study was planned to know the toxic effect of permethrin on immune
system and reversal effect of Curcuma longa if any on permethrin induced
immunotoxicity in mice. Approximate medium lethal dose (ALD50) of permethrin taken
into consideration for the study was 540 mg/kg. Mice were divided into eight different
groups each comprising of ten mice. The group C1 was administered corn oil and served
as vehicle control. The group C2 was administered ethanolic extract of Curcuma longa
rhizomes at the dose rate of 10 mg/kg and acted as plant control. Group T1 was given
1/40th of LD50 (13.5 mg/kg), group T2 was put on 1/30th of LD50 (18 mg/kg) and group
T3 received 1/20th of LD50 (27 mg/kg) of permethrin suspended in corn oil. Group T4
was given permethrin at dose rate of 1/40th of LD50 (13.5 mg/kg) along with ethanolic
extract of Curcuma longa rhizomes at the dose rate of 10 mg/kg.
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Keywords
Veterinary Pharmacology, studies