Synthesis, Characterization and Evaluation of some Substituted isoxazoles as nematicides against root-knot nematode (meloidogyne javanica).
| dc.contributor.advisor | Rajvir Singh | |
| dc.contributor.author | Chopra, Indu | |
| dc.date.accessioned | 2017-10-09T06:37:03Z | |
| dc.date.available | 2017-10-09T06:37:03Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | Isoxazole derivatives exhibit wide spectrum of biological activities. This nucleus has different agrochemical and pharmaceutical properties and has a lot of potential for their use in agrochemical (pesticides). Keeping this in mind, synthesis and bioevaluation of substituted isoxazoles (15-22 and 36-44) have been undertaken. Condensation of substituted aldehydes (1-4) and substituted acetophenones (5-6) refluxing in 20% ethanolic sodium hydroxide solution gave various substituted chalcones (7-14) in good yields. The reaction of chalcones (7-14) with hydroxylamine hydrochloride in presence of anhydrous sodium acetate gave substituted isoxazoles (15-22). Similarly substituted hydroxy isoxazoles (27-29) were prepared using substituted aldehydes (1, 3, 4) and hydroxy acetophenone (23). These compounds (27- 29) were further treated with epichlorohydrin in presence of catalytic amount potassium carbonate which yielded 3-(4-oxiranylmethoxyphenyl)-5-(4-chloro-/methyl- /2-chlorophenyl) isoxazoles (30-32). These compounds (30-32) were then reacted with substituted phenols (33-35) and yielded 3-{4-[3-(4-substitutedphenoxy)-2- hydroxypropoxy]phenyl}-5-(4-substitutedphenyl)isoxaz oles (36–44). The synthesized compounds were characterized by spectroscopic technique (NMR, IR) and elemental analysis data. All the synthesized compounds (15-22 and 36-44) were evaluated for nematicidal activity aginst root-knot nematode (Meloidogyne javanica) at 1000, 500, 250 and 125 ppm concentrations. It was found that compound 16 among 15-22 and compound 40 among compounds 36-44 were found to be most nematoxic. These compounds deserve for investigations for their possible use in agrochemicals for plant disease control. | en_US |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810032565 | |
| dc.keywords | Characterization, Evaluation, Nematicides , Nematode | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | CCSHAU | en_US |
| dc.sub | Chemistry | en_US |
| dc.subject | null | en_US |
| dc.theme | Synthesis, Characterization and Evaluation of some Substituted isoxazoles as nematicides against root-knot nematode (meloidogyne javanica). | en_US |
| dc.these.type | M.Sc | en_US |
| dc.title | Synthesis, Characterization and Evaluation of some Substituted isoxazoles as nematicides against root-knot nematode (meloidogyne javanica). | en_US |
| dc.type | Thesis | en_US |