Synthesis and studies on some carbamates as potential nematicidal agents
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Date
2011
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Publisher
CCSHAU
Abstract
The extensive use of pesticides together with synthetic fertilizers has caused a very rapid
increase in agriculture productivity since last many years. But threat is still persist from several
diseases caused by different insects/pests because one third of crops are lost due to these pests and
diseases. Among different pests, the plant parasitic nematodes cause significant losses in major crops in
India. So the reduction of losses caused by these pests is obvious strategy to increase food supply. The
nematodes, a tiny worm like creature mainly feed on roots and take their nutrition from plant cell
cytoplasm. Among nematodes, Meloidogyne javanica is most common species of root-knot nematode
worldwide. Except insecticides, there is no specific, effective and cheap nematicide available on which
one can depend to control nematodes. Also the use of these chemicals creating environmental problems
and hazards to non-target organisms.The biological activities shown by carbamates, their importance as
agrochemicals and as a part of our ongoing new nematicide development programme, a series of 3-
(substitutedphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one(14-25), substituted 2H-1-benzopyran-2-one
(42-45) and their derivatives carbamates (47-51) were synthesized. The chemical structures of newly
synthesized compounds were elucidated by IR, 1HNMR, and other physical and analytical data. The
synthesized compounds were evaluated for their nematicidal activity against root-knot nematode
(Meloidogyne javanica). The bioactive assay showed that compound 45 among 42-45 and compound
47-51 were most toxic to nematodes and showed 100 % mortality at all concentrations (upto 7.5 ppm).
The compounds showed spectacular prospects for further research and use in the field. The findings
suggested that the chalcone and coumarin framework is an attractive template for synthesis of
nematicides. These compounds needs further exploration for their possible use as nematicides and
deserve further investigation.
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Keywords
Carbamates, Aromatic compounds, Nematicides, Concentrates, Yields, Organic compounds, Biological phenomena, Meloidogyne javanica, Toxicity, Pesticides