Evaluation of Blood Levels of Enrofloxacin in Dogs with Renal Dysfunction

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dc.contributor.advisorIngole, K. H.
dc.contributor.authorNatu, K. V.
dc.date.accessioned2023-10-06T15:12:02Z
dc.date.available2023-10-06T15:12:02Z
dc.date.issued2022-02-25
dc.description.abstractThe present study entitled “Evaluation of blood levels of enrofloxacin in dogs with renal dysfunction” was conducted in Department of Veterinary Clinical Medicine, ethics and Jurisprudence, Mumbai Veterinary College, Parel, Mumbai. Six dogs with normal renal function and haemato-biochemical parameters necessitating enrofloxacin treatment were selected under control group whereas, six dogs with abnormal renal function and normal haemato-biochemical parameters necessitating enrofloxacin treatment were selected under study group. Renal dysfunction was confirmed by evaluation of serum creatinine and blood urea nitrogen values above the reference range and creatinine clearance less than the reference range. Enrofloxacin was administered after appropriate fluid therapy at the dose rate of 5 mg/kg intramuscularly and was repeated after 24 hours interval. Serial plasma samples were collected at specific time intervals and were analysed for blood levels of enrofloxacin and ciprofloxacin using HPLC method. Pharmacokinetic parameters of enrofloxacin showed significant increase (p<0.05) in values of AUC (μg/ml*hr), Cmax (μg/ml) and decrease in clearance (ml/h/kg) and considerable increase in t1/2 (hr.) in dogs with renal dysfunction. Pharmacokinetic parameters of ciprofloxacin showed significant increase (p<0.05) in values of Cmax(μg/ml), t1/2 (hours), AUC (μg/ml*hr), MRT (hours), significant decrease (p<0.05) in Vd (ml/kg) and highly significant decrease (P≤0.01) in clearance (ml/hr/kg) in dogs with renal dysfunction. The Cmax of enrofloxacin and ciprofloxacin after 2nd dosing of enrofloxacin was 22.76 % and 32.38% greater than after 1st dosing of enrofloxacin in dogs under study group. Minimum inhibitory concentration of most bacteria susceptible for enrofloxacin and ciprofloxacin was achieved either individually or by combined consideration. As dogs with renal dysfunction have hampered drug clearance at variable levels, it is essential to adjust the dose, considering the unnecessary elevation in Cmax values above MIC values in dogs with renal dysfunction.
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810198511
dc.keywordsVeterinary Clinical Medicine
dc.keywordsEthics
dc.keywordsJurisprudence
dc.keywordsBlood Levels
dc.keywordsEnrofloxacin
dc.keywordsDog
dc.keywordsRenal Dysfunction
dc.language.isoEnglish
dc.pages152
dc.publisherMAFSU, NAGPUR
dc.subClinical Veterinary Medicine, Ethics and Jurisprudence
dc.themeBlood Levels of Enrofloxacin in Dog
dc.these.typeM.V.Sc.
dc.titleEvaluation of Blood Levels of Enrofloxacin in Dogs with Renal Dysfunction
dc.typeThesis
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