STUDIES ON ANAESTHETIC EVALUATION OF PROPOFOL-THIOPENTONE SODIUM AS AN INDUCTION AND MAINTENANCE AGENT IN DOGS (Canis domestica)

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dc.contributor.advisorKelawala, N. H.
dc.contributor.authorManat, Dipakkumar L.
dc.date.accessioned2018-06-15T12:41:30Z
dc.date.available2018-06-15T12:41:30Z
dc.date.issued2001
dc.description.abstractA study on general anaesthesia using propofol alone (group I) and propofol-thiopentbne (group II) for induction and maintenance of anaesthesia after premedication with acepromazine was conducted in twelve clinically healthy dogs of either sex, allotted to two groups of six animals each. Anaesthesia was induced in overnight fasted dogs 20 min after premedication with acepromazine (0.05 mg/kg body weight i.m.) with intravenous propbfol @ 4 mg/kg body weight (group I) over a period of 90 sec and maintained over a minimum period of 30 min with an average 2.5 times (2 to 3) increments which was 50% of induction dose with a mean maintenance dose of 5.0 ± 0.45 mg/kg body weight of propofol i.v.; whereas, in animals of group II, it was induced with a propofol-thiopentone mixture which was prepared by drawing up individual doses of propofol (2 mg/kg) and 2.5% thiopentone (5 mg/kg) in two separate syringes. The drugs were then mixed in the same syringe, resulting in a (1 vol:l vol) mixture which was administered i.v. via venous catheter over 90-120 seconds. In group II, anaesthesia was maintained by mean maintenance dose of 0.55 ±0.1 mg/kg body weight i.v. of propofol and 1.38 ±0.1 mg/kg body weight i.v. of thiopentone that was an average 2.75 increments (2 to 3) with 10% of induction dose of each drug. Different clinical parameters related to anaesthesia, recovery times, vital signs and complications, if any, were recorded before premedication and at 0, 10, 20, 30 and 60 min. after induction. Different haematobiochemical parameters were studied at 0, 15, 45 min. and 24 hours postinduction. Induction of anaesthesia in animals of both the groups were smooth and satisfactory without any complications, however, it was comparatively faster in animals of group I wherein only propofol was used for induction. Duration of post-induction apnoea was less when propofol was used with thiopentone than when used alone. Duration of anaesthesia was longer in the animals of group II wherein a mixture of propofol-thiopentone anaesthesia used. Mean time to head lift, time to sternal recumbency and complete recovery time were significantly longer witli propofol-thiopentone group than propofol group. Recovery was smooth in all the animals without any major complications. There was significant increase in the heart rate and a decrease in respiratory rate in the both groups. There was nonsignificant decrease in body temperature in animals of group I, whereas, it was significantly decreased in animals of group II. There was nonsignificant decrease in the ojcygen saturation in animals of both the groups. Haematological studies during and upto 24 hrs of induction revealed nonsignificant reduction in haemoglobin concentration and number of lymphocytes in both the groups. TLC was nonsignificantly increased in the animals of group I, whereas, it decreased in the animals of group II and PCV decreased significantly in both the groups. Biochemical studies during and upto 24 hrs. after induction revealed significant increase in blood glucose and plasma creatinine and nonsignificant increase in blood urea nitrogen and total plasma protein in both the groups. The present study indicated that propofol in combination with thiopentone reduces the dose related side effects of propofol at the same time is cost effective and can be safely used in routine clinical practice as compared to propofol alone.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810053485
dc.keywordsSTUDIES ON ANAESTHETIC EVALUATION, PROPOFOL-THIOPENTONE SODIUM, AN INDUCTION AND MAINTENANCE AGENT IN DOGS (Canis domestica)en_US
dc.language.isoenen_US
dc.publisherAAU, Ananden_US
dc.research.problemSTUDIES ON ANAESTHETIC EVALUATION OF PROPOFOL-THIOPENTONE SODIUM AS AN INDUCTION AND MAINTENANCE AGENT IN DOGS (Canis domestica)en_US
dc.subVeterinary Surgeryen_US
dc.subjectVETERINARY SURGERYen_US
dc.subjectA STUDYen_US
dc.themeSTUDIES ON ANAESTHETIC EVALUATION OF PROPOFOL-THIOPENTONE SODIUM AS AN INDUCTION AND MAINTENANCE AGENT IN DOGS (Canis domestica)en_US
dc.these.typeM.V.Sc.en_US
dc.titleSTUDIES ON ANAESTHETIC EVALUATION OF PROPOFOL-THIOPENTONE SODIUM AS AN INDUCTION AND MAINTENANCE AGENT IN DOGS (Canis domestica)en_US
dc.typeThesisen_US
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