TOXICOPATHOLOGICAL STUDIES ON 'NALED TECHNICAL' IN RATS AND DOGS
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Date
1989
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AAU, Anand
Abstract
The study on toxicopathological effects of naled technical was undertaken in rats and dogs. Naled technical (1-2, dibromo 2,2 dichloroethyl dimethyl phosphate) was given intragastrically to obtain the oral LD50 in laboratory inbred albino rats (Ratus morvegicus) which was found to be 425 mg/kg body weight (P0.05). Rtas of either sex were divided into four groups each comprising of three male and three female. Group I was provided with plain ground feed (without naled) which served as control. Group II, Group III and Group IV were given 12.5 25 and 50 mg naled per kg of feed, respectively. Weekly body weight was recorded and experiment was conducted in natural day-night rhythm. Initially u[pto four weeks, rise in body weight was observed compared to control which started decreasing after seven weeks of experiment.
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VETERINARY PATHOLOGY, A STUDY