CONTINUOUS RATE INFUSION ANAESTHESIA WITH DEXMEDETOMIDINEMIDAZOLAM-KETAMINE-LIGNOCAINE IN DEXMEDETOMIDINEBUTORPHANOL-MIDAZOLAM-KETAMINE ANAESTHETISED DOGS
| dc.contributor.advisor | S, Sooryadas | |
| dc.contributor.author | VERMA, ANIKSHIT | |
| dc.date.accessioned | 2021-01-19T06:28:42Z | |
| dc.date.available | 2021-01-19T06:28:42Z | |
| dc.date.issued | 2019-12-11 | |
| dc.description.abstract | Six adult dogs of different breeds and ages, belonging to eithersex and categorised as ASA class I or II, which were posted for various elective soft tissue and orthopaedic surgical procedures in the Department of Surgery and Radiology, College of Veterinary and Animal Sciences, Pookode, Wayanad, were anaesthetised using a combination of dexmedetomidine @ 5 µg/kg body weight, butorphanol @ 0.2 mg/kg body weight, midazolam @ 0.2 mg/kg body weight and ketamine @ 5 mg/kg body weight, given intramuscularly. Following induction, the animals were intubated and connected to the circle system of anaesthetic machine to provide oxygen. Thereafter, a loading dose of 2% lignocaine intravenous preparation was administered @ 2 mg/kg body weight, intravenously. Following the loading dose of lignocaine, anesthesia was maintained using a continuous rate infusion of dexmedetomidine (@ 2 µg/kg/h), midazolam (@ 3 µg/kg/min), lignocaine (@ 50 µg/kg/min) and ketamine (@ 40 µg/kg/min). The induction was smooth, with no signs of anxiety and no laryngeal reflex, allowing easy intubation in 7.33 ± 3.72 min. The maintenance of anaesthesia was excellent. Additional top up injectable drugs or inhalant agents were not required, throughout the surgeries. The eyeballs were positioned ventro-medially in all six animals studied. Heart rate and rate of respiration were found decreased following induction. End tidal carbon dioxide values were initially high, and eucapnia was maintained using manual assisted ventilation, till the effects of opioid weaned off. The invasive and non-invasive blood pressure values were initially high, which slowly dropped down towards the normal physiological range. A decrease in rectal temperature was observed. The blood gases, electrolytes and haematological values did not show any significant variation from their normal reference values. Serum glucose values were observed to be significantly high. Following cessation of the continuous rate infusion, the animals rejected the endotracheal tube in 42 ± 9.87 minutes. The recovery was smooth and uneventful. From the study, it is concluded that dexmedetomidine-butorphanol-midazolam-ketamine combination intramuscular @ 5 µg/kg, @ 0.2 mg/kg, @ 0.2 mg/kg and @ 5 mg/kg respectively, followed by an intravenous loading dose of lignocaine @ 2 mg/kg and a continuous rate intravenous infusion of dexmedetomidine-midazolam-lignocaine-ketamine @ 2 µg/kg/h, 3 µg/kg/min, 50 µg/kg/min and 40 µg/kg/min respectively, in normal saline, effectively maintains anaesthesia for various soft tissue and orthopaedic surgeries. | en_US |
| dc.identifier.uri | https://krishikosh.egranth.ac.in/handle/1/5810160410 | |
| dc.keywords | Meloxicam,Dexmedetomidine,Midazolam ,Ketamine,Butorphanol,Lignocaine,NON-INVASIVE BLOOD PRESSURE (NIBP) ,INVASIVE BLOOD PRESSURE ,END TIDAL CARBON DIOXIDE (EtCO2) | en_US |
| dc.language.iso | English | en_US |
| dc.pages | 89 | en_US |
| dc.publisher | COLLEGE OF VETERINARY AND ANIMAL SCIENCES, POOKODE WAYANAD | en_US |
| dc.research.problem | ANAESTHESIA WITH DEXMEDETOMIDINEMIDAZOLAM-KETAMINE-LIGNOCAINE IN DEXMEDETOMIDINEBUTORPHANOL-MIDAZOLAM-KETAMINE ANAESTHETISED DOGS | en_US |
| dc.sub | Veterinary Surgery and Radiology | en_US |
| dc.theme | CONTINUOUS RATE INFUSION ANAESTHESIA WITH DEXMEDETOMIDINEMIDAZOLAM-KETAMINE-LIGNOCAINE IN DEXMEDETOMIDINEBUTORPHANOL-MIDAZOLAM-KETAMINE ANAESTHETISED DOGS | en_US |
| dc.these.type | M.V.Sc. | en_US |
| dc.title | CONTINUOUS RATE INFUSION ANAESTHESIA WITH DEXMEDETOMIDINEMIDAZOLAM-KETAMINE-LIGNOCAINE IN DEXMEDETOMIDINEBUTORPHANOL-MIDAZOLAM-KETAMINE ANAESTHETISED DOGS | en_US |
| dc.type | Thesis | en_US |