PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS

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dc.contributor.advisorThaker, A. M.
dc.contributor.authorPATEL, JATINKUMAR HARGOVINDDAS
dc.date.accessioned2018-06-08T12:16:20Z
dc.date.available2018-06-08T12:16:20Z
dc.date.issued2008
dc.description.abstractLevofloxacin is the active L - isomer of the racemate ofloxacin, a fluorinated quinolone has broad-spectrum activity and good antibacterial activity at low plasma/tissue concentration. The present study was designed to investigate pharmacokinetics of levofloxacin following single dose intravenous and oral administration at the dose rate of 10 mg/kg of body weight and to evaluate safety after repeated administration (10 mg/kg) of levofloxacin at 12 hours interval for 14 days in layer birds. Drug concentration in serum was determined using High Performance Liquid Chromatography (HPLC). Following intravenous administration, the serum drug concentration-time curves were analyzed by non-compartmental approach. Following intravenous administration the therapeutically effective serum concentration of levofloxacm > 0.13 µg/ml was maintamed for up to 12 hours. Based on the serum drug concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.08 ± 0.05 hours), apparent volume of distribution (Vd(area)) (4.02 ± 0.079 1/kg), volume of distribution of drug at steady-state (Vd(ss)) (3.23 ± 0.055 1/kg), total body clearance (CIB) (15.09 ± 0.21 ml/min/kg), area under serum drug concentration-time curve (AUG) (11.07 ± 0.14 µg.h/ml), area under first moment of curve (AUMC) (39.56 ± 0.89 µg.h2/ml) and mean residence time (MRT) (3.57 ± 0.052 hours) were determined.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810050255
dc.keywordsPHARMACOKINETICS, SAFETY STUDY, LEVOFLOXACIN IN LAYER BIRDSen_US
dc.language.isoenen_US
dc.publisherAAU, Ananden_US
dc.research.problemPHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDSen_US
dc.subVeterinary Pharmacologyen_US
dc.subjectVETERINARY PHARMACOLOGYen_US
dc.subjectA STUDYen_US
dc.themePHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDSen_US
dc.these.typeM.V.Sc.en_US
dc.titlePHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDSen_US
dc.typeThesisen_US
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