PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS
dc.contributor.advisor | Thaker, A. M. | |
dc.contributor.author | PATEL, JATINKUMAR HARGOVINDDAS | |
dc.date.accessioned | 2018-06-08T12:16:20Z | |
dc.date.available | 2018-06-08T12:16:20Z | |
dc.date.issued | 2008 | |
dc.description.abstract | Levofloxacin is the active L - isomer of the racemate ofloxacin, a fluorinated quinolone has broad-spectrum activity and good antibacterial activity at low plasma/tissue concentration. The present study was designed to investigate pharmacokinetics of levofloxacin following single dose intravenous and oral administration at the dose rate of 10 mg/kg of body weight and to evaluate safety after repeated administration (10 mg/kg) of levofloxacin at 12 hours interval for 14 days in layer birds. Drug concentration in serum was determined using High Performance Liquid Chromatography (HPLC). Following intravenous administration, the serum drug concentration-time curves were analyzed by non-compartmental approach. Following intravenous administration the therapeutically effective serum concentration of levofloxacm > 0.13 µg/ml was maintamed for up to 12 hours. Based on the serum drug concentrations, various pharmacokinetic parameters like elimination half-life (t1/2β) (3.08 ± 0.05 hours), apparent volume of distribution (Vd(area)) (4.02 ± 0.079 1/kg), volume of distribution of drug at steady-state (Vd(ss)) (3.23 ± 0.055 1/kg), total body clearance (CIB) (15.09 ± 0.21 ml/min/kg), area under serum drug concentration-time curve (AUG) (11.07 ± 0.14 µg.h/ml), area under first moment of curve (AUMC) (39.56 ± 0.89 µg.h2/ml) and mean residence time (MRT) (3.57 ± 0.052 hours) were determined. | en_US |
dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810050255 | |
dc.keywords | PHARMACOKINETICS, SAFETY STUDY, LEVOFLOXACIN IN LAYER BIRDS | en_US |
dc.language.iso | en | en_US |
dc.publisher | AAU, Anand | en_US |
dc.research.problem | PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS | en_US |
dc.sub | Veterinary Pharmacology | en_US |
dc.subject | VETERINARY PHARMACOLOGY | en_US |
dc.subject | A STUDY | en_US |
dc.theme | PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS | en_US |
dc.these.type | M.V.Sc. | en_US |
dc.title | PHARMACOKINETICS AND SAFETY STUDY OF LEVOFLOXACIN IN LAYER BIRDS | en_US |
dc.type | Thesis | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- PATEL JATINKUMAR HARGOVINDDAS.pdf
- Size:
- 8.63 MB
- Format:
- Adobe Portable Document Format
- Description:
- M.V.Sc. (Veterinary Pharmacology) Dissertation
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: