Immunopathological response of the duck (Anas platyrrhyncos domesticus) to sublethal dose of selected agro-chemicals
| dc.contributor.advisor | Valsala, K V | |
| dc.contributor.author | Vijayan, N | |
| dc.contributor.author | KAU | |
| dc.date.accessioned | 2020-02-29T08:31:15Z | |
| dc.date.available | 2020-02-29T08:31:15Z | |
| dc.date.issued | 1998 | |
| dc.description | PhD | en_US |
| dc.description.abstract | The study was conducted with the objective of assessing the teratologic, embryotoxic and immunopathologic effects of two agro-chemicals carbofuran and 2,4-D used in agricultural operations, on duck embryos and ducklings. The embryological studies included the observation on the embryonic defects and weight of the lymphoid organs along with the histopathologic and ultrastructural studies of the lymphoid organs like the bursa, spleen and thymus. The results showed that the contamination of the eggs with the above chemicals caused moderate deleterious effects on the lymphoid system, though no teratologic effects could be observed. The histological and ultrastructural changes also confirmed the deleterious effects at the tissue and cellular level. The immune system of the ducks exposed to the above chemicals for two different durations were assessed using a battery of tests. The humoral immune system was assessed based on the body weight, lymphoid organ weight, haematological evaluation, serum biochemical evaluation and the evaluation of HI titre against NDV. The cell-mediated immune system was assessed by the skin reactivity tests to DNCB and PHA. LMIT and GVHR were also employed to assess the cell-mediated immune system. The histological and ultrastructural studies were also conducted after six weeks and ten weeks of the experiment. The assessment of the immunological profile employing these elegant tests revealed that these agro-chemicals caused mild but significant suppression of the cell-mediated and humoral immune response. By this investigation it was clarified that these agro-chemicals have mild to moderate degree of immunotoxic effect when exposed for a short duration, but the changes were severe when exposed for longer duration. From the .studies, it was demonstrated that the immunotoxic effect of carbofuran is more compared to 2,4-D (herbicide) and the changes were dose and time dependent. | en_US |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810143994 | |
| dc.keywords | Carbofuran, Embryotoxicity, Immunopathological response, Cell-mediated immune response, Ultrastructural pathology | en_US |
| dc.language.iso | en | en_US |
| dc.pages | 144 | en_US |
| dc.publisher | Centre of Excellence in Pathology, College of Veterinary and Animal Sciences, Mannuthy | en_US |
| dc.sub | Veterinary Pathology | en_US |
| dc.subject | null | en_US |
| dc.theme | Immunopathological response of the duck | en_US |
| dc.these.type | Ph.D | en_US |
| dc.title | Immunopathological response of the duck (Anas platyrrhyncos domesticus) to sublethal dose of selected agro-chemicals | en_US |
| dc.type | Thesis | en_US |