AN ASSESSMENT OF THE IMMUNOPATHOLOGICAL RESPONSE IN BOVINE MASTITIS
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Date
1996
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COLLEGE OF VETERINARY AND ANIMAL SCIENCE,MANNUTHY
Abstract
The i^nunopathologlcal response o£ cows suffering fro.
hUnroal and suh-olinlcal .astifis was evafuafed and compared
"Tth healthy non-.astitlc cows using various i^unological
markers.
Significant enhancement of the humoral immune response
was noticed in suh-clinical cases of mastitis, whereas those
suffering from clinical mastitis had only a slight difference
as ccmpared to the healthy cows.
Elevated T lymphocyte count was noticed in acute ,38 33
t 0.8i, and chronic ,35 r 0.93%) stages of mastitis. Those
Offering from sub-clinical cases had a slight reduction in
the mean T cell count (299- 83%) a=s compared to that of the
healthy non-mastitic cows (31.3 ± 1.42%).
Three hundred and thirty one samples ,22.23%, were sub-
Clinically positive out of the 1489 samples examined by
California Mastitis Test • OOuu^t Of ,t-hv.e 520 samples subjected
or cultural examination 186 were cultur,.!! n n
tiJie culturally positive. Fifty
pen ceo,
SCaphylococci, which included both coagulase positive and
coagulase negative group, other pathogenic organisms isolated
included Streptococci, Corynebacterium, Pseudomonas, and gram
positive bacilli. Direct correlation between the somatic cell
count and California Mastitis Test score was noticed.
Neutrophils were the predominant cells in the milk samples.
The major pathogens were more sensitive to Gentamicin
(98.21%) followed by Pefloxacine (96.42%), Chloramphenecol
(91.07%), Streptomycin (82.14%), Cotrimoxazole (80.35%),
Ampicillin (73.21%), Oxytetracycline (71.43%) and Penicillin
(60.71%) .
Haematological examination of sub-clinical cases revealed
leukopaenia. Slight increase in the serum total protein was
noticed in sub-clinical cases.
Gross changes of mastitis was noticed in 18 mammary
glands tissues examined. Histologically out of the 336 glands
examined, 271 were having inflammatory changes of varying
degrees. Acini as well as interstitium contained inflammatory
cells in 37.68 per cent of cases. The entire parenchyma was
affected in 14.49 per cent a cases.
Oedematous appearance of the supramammary lymphnodes was
noticed. Microscopically marked expansion of the cortex by
numerous lymphoid follicles in various stages of activity was
noticed.
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