PATHOGENESIS AND TREATMENT OF IMMATURE ARCARIDIA GALLI INFECTION IN EXPERIMENTALLY INFECTED CHICKEN
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Date
1992-07-27
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES Mannuthy - Trichur
Abstract
In a study conducted on the pathogenesis and treatment
of Ascarldia galli in experimentally infected chicken at
different developmental stages of the worm, it had been
found that droopiness, whitish diarrhoea, marked reduction
in body weight gain, haemorrhage and congestion at different
parts of the intestinal mucosa and frothy or blood tinged
intestinal contents were the main clinico pathological
changes.
Histopathological observations in the small intestine
were signs of enteritis, catarrhal changes, villar
proliferation, desquamation of sub epithelium and villar
tips and mild congestion and haemorrhage. A tissue phase
was observed in the life-cycle of the nematode at 20th day
post infection indicated by the presence of cut sections of
the larvae in the mucosal and submucosal regions.
Haematologically, a decrease in the total erythrocyte
count, an initial leucopenia followed by leucocytosis,
reduction in packed cell volume and percentage of
haemoglobin, an increase in the erythrocyte sedimentation
rate, percentage of heterophils, eosinophils,' mean
corpuscular volume and mean corpuscular haemoglobin values
and a reduction in the percentage of lymphocytes, monocytes
and mean corpuscular haemoglobin concentration and an
initial basopenia followed by basophilia were observed in
infected chicks.
For treatment, out of the four anthelmintics tried,
namely piperazine hydrate, albendazole, morantel citrate and
ivermectin against the infection, albendazole at 50 mg/kg
body weight was found to be the most effective, closely
followed by morantel citrate at 50 mg/kg body weight and
then piperazine hydrate at 500 mg/kg body weight.
Ivermectin at 1 mg/kg body weight subcutaneously was found
to be the least effective.
The present study with morantel citrate appeared to be
the first of its kind as far as it's use against
ascaridiasis in poultry was concerned
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