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Assam Agricultural University, Jorhat

Assam Agricultural University is the first institution of its kind in the whole of North-Eastern Region of India. The main goal of this institution is to produce globally competitive human resources in farm sectorand to carry out research in both conventional and frontier areas for production optimization as well as to disseminate the generated technologies as public good for benefitting the food growers/produces and traders involved in the sector while emphasizing on sustainability, equity and overall food security at household level. Genesis of AAU - The embryo of the agricultural research in the state of Assam was formed as early as 1897 with the establishment of the Upper Shillong Experimental Farm (now in Meghalaya) just after about a decade of creation of the agricultural department in 1882. However, the seeds of agricultural research in today’s Assam were sown in the dawn of the twentieth century with the establishment of two Rice Experimental Stations, one at Karimganj in Barak valley in 1913 and the other at Titabor in Brahmaputra valley in 1923. Subsequent to these research stations, a number of research stations were established to conduct research on important crops, more specifically, jute, pulses, oilseeds etc. The Assam Agricultural University was established on April 1, 1969 under The Assam Agricultural University Act, 1968’ with the mandate of imparting farm education, conduct research in agriculture and allied sciences and to effectively disseminate technologies so generated. Before establishment of the University, there were altogether 17 research schemes/projects in the state under the Department of Agriculture. By July 1973, all the research projects and 10 experimental farms were transferred by the Government of Assam to the AAU which already inherited the College of Agriculture and its farm at Barbheta, Jorhat and College of Veterinary Sciences at Khanapara, Guwahati. Subsequently, College of Community Science at Jorhat (1969), College of Fisheries at Raha (1988), Biswanath College of Agriculture at Biswanath Chariali (1988) and Lakhimpur College of Veterinary Science at Joyhing, North Lakhimpur (1988) were established. Presently, the University has three more colleges under its jurisdiction, viz., Sarat Chandra Singha College of Agriculture, Chapar, College of Horticulture, Nalbari & College of Sericulture, Titabar. Similarly, few more regional research stations at Shillongani, Diphu, Gossaigaon, Lakhimpur; and commodity research stations at Kahikuchi, Buralikson, Tinsukia, Kharua, Burnihat and Mandira were added to generate location and crop specific agricultural production packages.

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20161
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Subject: Veterinary Pharmacology and Toxicology × Author: RAHMAN, FARIDA × End date: 2017 × Type: Thesis ×
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    ThesisItemOpen Access
    ROLE OF NANOCURCUMIN ON EXPERIMENTALLY INDUCED HEPATOTOXICITY IN RATS
    (Assam Agricultural University, Khanapara, Guwahati, 2016-07) RAHMAN, FARIDA; Sarma, Jadav
    The present study evaluated the protective effect of nanocurcumin against carbon tetrachloride (CCl4) and paracetamol induced hepatotoxicity. A total of 96 albino rats of Wistar strain were divided into two groups each for CCl4 and paracetamol having eight subgroups consist of six rats per group. In CCl4 induced hepatic model, Group I served as normal control group [olive oil i/p, at the dose rate of 2 ml/kg body weight on the day of administration of CCl4 to the treatment groups and CMC (1% w/v) p.o., 1 ml/100g body weight for 4 weeks], Group II served as positive control (CCl4 2 ml/kg in olive oil by i/p), Group III (CCl4 2 ml/kg in olive oil by i/p + silymarin 100 mg/kg p.o.), Group IV (CCl4 2 ml/kg in olive oil by i/p + nanocurcumin 40 mg/kg p.o), Group V (CCl4 2 ml/kg in olive oil by i/p + nanocurcumin 80 mg/kg p.o.), Group VI (CCl4 2 ml/kg in olive oil by i/p + nanocurcumin 160 mg/kg p.o.), Group VII (CCl4 2 ml/kg in olive oil by i/p + curcumin 160 mg/kg p.o.), Group VIII (CCl4 2 ml/kg in olive oil by i/p + turmeric 160 mg/kg p.o.) for four consecutive weeks. In the paracetamol induced hepatotoxicity model, Group I served as the normal control group (CMC 1 ml/100g body weight), Group II served as positive control (parcetamol 500 mg/kg in CMC p.o.), Group III (parcetamol 500 mg/kg in CMC p.o. + silymarin 100 mg/kg p.o.), Group IV (parcetamol 500 mg/kg in CMC p.o. + nanocurcumin 40 mg/kg p.o.), Group V (parcetamol 500 mg/kg in CMC p.o. + nanocurcumin 80 mg/kg p.o.), Group VI (parcetamol 500 mg/kg in CMC p.o. + nanocurcumin 160 mg/kg p.o.), Group VII (parcetamol 500 mg/kg in CMC p.o. + curcumin 160 mg/kg p.o.), Group VIII (parcetamol 500 mg/kg in CMC p.o. + turmeric 160 mg/kg p.o.) for four consecutive weeks. Blood and liver samples were collected for biochemical and histopathological analysis respectively. The present study revealed that CCl4 and paracetamol elevated the activities of LDH and liver enzymes (AST, ALT, ALP) and increased bilirubin, uric acid and malondialdehyde (MDA) level. On the other hand, CCl4 and paracetamol decreased the biochemical parameters, such as total protein, albumin, and globulin. After treatment with nanocurcumin (40, 80,160 mg/kg body weight) it was found that the activity of liver enzymes (AST, ALT, ALP), LDH, bilirubin, uric acid and MDA level decreased significantly, here as the level of total protein, albumin, and globulin was found to be increased significantly in a dose dependent manner with the nanocurcumin treatment. In the histopathological study it was observed that administration of nanocurcumin decreased the fatty and necro-inflammatory changes of liver.