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Assam Agricultural University, Jorhat

Assam Agricultural University is the first institution of its kind in the whole of North-Eastern Region of India. The main goal of this institution is to produce globally competitive human resources in farm sectorand to carry out research in both conventional and frontier areas for production optimization as well as to disseminate the generated technologies as public good for benefitting the food growers/produces and traders involved in the sector while emphasizing on sustainability, equity and overall food security at household level. Genesis of AAU - The embryo of the agricultural research in the state of Assam was formed as early as 1897 with the establishment of the Upper Shillong Experimental Farm (now in Meghalaya) just after about a decade of creation of the agricultural department in 1882. However, the seeds of agricultural research in today’s Assam were sown in the dawn of the twentieth century with the establishment of two Rice Experimental Stations, one at Karimganj in Barak valley in 1913 and the other at Titabor in Brahmaputra valley in 1923. Subsequent to these research stations, a number of research stations were established to conduct research on important crops, more specifically, jute, pulses, oilseeds etc. The Assam Agricultural University was established on April 1, 1969 under The Assam Agricultural University Act, 1968’ with the mandate of imparting farm education, conduct research in agriculture and allied sciences and to effectively disseminate technologies so generated. Before establishment of the University, there were altogether 17 research schemes/projects in the state under the Department of Agriculture. By July 1973, all the research projects and 10 experimental farms were transferred by the Government of Assam to the AAU which already inherited the College of Agriculture and its farm at Barbheta, Jorhat and College of Veterinary Sciences at Khanapara, Guwahati. Subsequently, College of Community Science at Jorhat (1969), College of Fisheries at Raha (1988), Biswanath College of Agriculture at Biswanath Chariali (1988) and Lakhimpur College of Veterinary Science at Joyhing, North Lakhimpur (1988) were established. Presently, the University has three more colleges under its jurisdiction, viz., Sarat Chandra Singha College of Agriculture, Chapar, College of Horticulture, Nalbari & College of Sericulture, Titabar. Similarly, few more regional research stations at Shillongani, Diphu, Gossaigaon, Lakhimpur; and commodity research stations at Kahikuchi, Buralikson, Tinsukia, Kharua, Burnihat and Mandira were added to generate location and crop specific agricultural production packages.

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Subject: Veterinary Epidemiology and Preventive Medicine × Author: MUKHERJEE, SHYAMANANDA × End date: 2019 × Start date: 2016 × Type: Thesis × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    OUTER MEMBRANE VESICLE (OMV) OF Pasteurella multocida AS POTENTIAL IMMUNOGEN FOR PIG
    (Assam Agricultural University, Khanapara, Guwahati, 2016-07) MUKHERJEE, SHYAMANANDA; Mahato, G.
    The present study was undertaken to evaluate the immunogenic potential of Outer Membrane Vesicles (OMVs) and bacterin vaccine and their comparison. Extractions were made from a highly pathogenic pig isolate of Pasteurella multocida of capsular type A. For the study, isolation of P. multocida was attempted from apparently healthy, ailing and dead pigs. Following screening of the 171 field samples collected from various places, 17 (9.94 %) were found to be positive for P. multocida. Fourteen of the 17 isolates subjected to PCR targeting species-specific gene revealed a distinct band of 460 bp, which was a confirmation of the isolates as P. multocida. Among the confirmed P. multocida isolates, nine were identified as capsular type A (1044 bp), while the remaining five were capsular type D (657 bp), based on multiplex cap-PCR results, targeting hyaD-hyaC and dcbF genes, respectively. Both OMVs and bacterin were extracted from the most pathogenic porcine isolate of P. multocida capsular type A selected on the basis of pathogenicity trial in mice. Vaccines were prepared from the OMVs extract and bacterin of P. multocida and immunized to pigs. Following immunization with vaccines prepared from both the extracted OMVs and bacterin in natural host, pig through intramuscular (i/m) route, a gradual increase in the mean serum antibody titre was observed in both the immunized groups. The vaccine prepared from the OMVs extract showed peak antibody titre on 60th day (6.40± 0.19) post-vaccination. On the other hand, the vaccine preparation with the bacterin extract showed peak titre on 28th day (6.10± 0.14) of post-immunization and no significant difference was observed between the vaccine preparations throughout the study period (upto 90 days). Based on the statistical analysis of the mean serum antibody titre at different days post-immunization with the two preparations, no significant difference was observed between the two vaccine preparations of P. multocida. The post vaccinated serum samples collected on different days were subjected for protection test in mice. The result of passive mouse protection test revealed that the 21st and 28th day post vaccination serum sample (OMV vaccine) and 28th day serum sample (bacterin vaccine) produced (100%) protection in mice.