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Chaudhary Sarwan Kumar Himachal Pradesh Agriculture University, Palampur

Himachal Pradesh Krishi Vishvavidyalaya (renamed as Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya in June, 2001) was established on 1st November, 1978.The College of Agriculture (established in May, 1966) formed the nucleus of the new farm University. It is ICAR accredited and ISO 9001:2015 certified institution. The Indian Council of Agricultural Research has ranked this University at eleventh place among all farm universities of the country. The University has been given the mandate for making provision for imparting education in agriculture and other allied branches of learning, furthering the advancement of learning and prosecution of research and undertaking extension of such sciences, especially to the rural people of Himachal Pradesh. Over the years, this University has contributed significantly in transforming the farm scenario of Himachal Pradesh. It has developed human resources, varieties and technologies and transferred these to farming community enabling the State to receive the “Krishikarman award” of Govt. of India four times in row for food grain production among small states of the country. Today, the State has earned its name for hill agricultural diversification and the farming community has imposed its faith in the University.

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Subject: Veterinary Pharmacology and Toxicology × Author: Sharma, Navjot × End date: 2017 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON AMELIORATIVE POTENTIAL OF SEABUCKTHORN AGAINST AFLATOXIN INDUCED HEPATOTOXICITY IN POULTRY
    (CSKHPKV, Palampur, 2014) Sharma, Navjot; Varshneya, C.
    The present investigation was undertaken to study the ameliorative potential of seabuckthorn (leaves and pulp) in aflatoxin induced hapatotoxicity in poultry. A total of 210, day old broiler chicks were used for studying the growth performance, biochemical parameter and antioxidant status for the period of 4 weeks. 70% methanolic extracts of seabuckthorn leaves and pulp were fed to broiler chicks @ 1000ppm in feed . Glucomannan was mixed in feed @ 1g/kg whereas, aflatoxin was added @ 400ppb. The aflatoxin treatment significantly (P<0.05) reduced weight gain and increased FCR. The seabuckthorn (leaves and pulp extract) alone significantly (P<0.05) improved the growth performance. AF treatment produced a significant (P<0.05) decrease in total serum proteins, albumin, globulin, cholesterol, triglycerides and HDL and significant (P<0.05) increase in AST, ALT, ALP, LDH and total serum billirubin. However, seabuckthorn (leaves and pulp extract) and glucomannan supplementation significantly (P<0.05) restored these biochemical parameters to control levels. In aflatoxin treated groups the malondialdehyde (MDA) level of liver, kidney and blood was significantly (P<0.05) increased whereas, GSH, catalase, SOD and GPx levels were significantly (P<0.05) decreased, while there was a significant (P<0.05) increase in levels of MDA, GSH, catalase, SOD and GPx in liver of chicks fed on seabuckthorn. The combined dietary supplementation of AF + SBT leaves , AF + SBT pulp, and AF +GM produced significant (P<0.05) decrease in lipid peroxidation and an increase GSH, Catalase, SOD and GPx level of liver, kidney and blood, respectively. Histopathological lesions in the liver were severe in aflatoxin group with marked congestion of hepatic sinusoids, focal haemorrhages, centro-lobular fatty cytoplasmic vacuolation and or necrosis, biliary hyperplasia, severe degeneration of hepatocytes, dilation of central veins, bile duct proliferation and least severe in group (AF+GM) followed by groups fed with SBT (leaves and pulp extract) and there were no lesions in chicks fed with SBT (leaves and pulp) alone. On the basis of growth performance, biochemical parameters, antioxidant activity and histopathology of liver tissues, it can be concluded that dietary supplementation of seabuckthorn is capable of ameliorating the aflatoxin induced hepatotoxicity in poultry.