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Chaudhary Sarwan Kumar Himachal Pradesh Agriculture University, Palampur

Himachal Pradesh Krishi Vishvavidyalaya (renamed as Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya in June, 2001) was established on 1st November, 1978.The College of Agriculture (established in May, 1966) formed the nucleus of the new farm University. It is ICAR accredited and ISO 9001:2015 certified institution. The Indian Council of Agricultural Research has ranked this University at eleventh place among all farm universities of the country. The University has been given the mandate for making provision for imparting education in agriculture and other allied branches of learning, furthering the advancement of learning and prosecution of research and undertaking extension of such sciences, especially to the rural people of Himachal Pradesh. Over the years, this University has contributed significantly in transforming the farm scenario of Himachal Pradesh. It has developed human resources, varieties and technologies and transferred these to farming community enabling the State to receive the “Krishikarman award” of Govt. of India four times in row for food grain production among small states of the country. Today, the State has earned its name for hill agricultural diversification and the farming community has imposed its faith in the University.

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Subject: Veterinary Pathology × Author: Thakur, Shalini × End date: 2017 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON THE EFFECTS OF PLANT BASED EXTRACT AGAINST Escherichia coli INFECTION IN BROILERS
    (CSKHPKV, Palampur, 2016-07-25) Thakur, Shalini; Asrani, R.K.
    The present study was planned with a view to observe the effects of methanolic extract of aerial parts of Artemisia nilagirica on growth, mortality, clinical signs, biochemical, pathological and ultrastructural changes in broiler chicks infected with E. coli. Three hundred thirty day old broiler chicks were randomly divided into six groups. The LD50 dose of E. coli was determined in a pilot experiment which was found to be 1x107 cfu ml-1. Plain E. coli infection, E. coli infection and methanolic extract (0.5g), E. coli infection and methanolic extract (1g), E. coli infection and methanolic extract (2g), methanolic extract (2g) and only feed was given to group(s) 1, 2, 3, 4, 5 and 6, respectively. E. coli infection was given on 7th day. Methanolic extract was given in water from day 4 to day 21. Results of present study showed that E. coli infected groups exhibited clinical signs of whitish diarrhea, anorexia, drooped wings, ruffled feathers, laboured and shallow breathing, huddling, dullness and depression. Higher values of ALT, AST, enzymatic creatinine, cholesterol, lower total protein and lower albumin values was observed in the plain infected group as compared to the control birds. However, in the combination groups (group 2, 3 and 4) the values were significantly less as compared the plain infected group (group 1). Grossly, in the group 1 fibrinous perihepatitis, fibrinous pericarditis, airsacculitis, splenomegaly and peritonitis were observed mainly. However, in the combination groups the gross lesions of significantly less intensity were observed. Microscopically, the liver and heart of group 1 revealed perihepatitis, pericarditis, vacuolar changes, leukocytic infiltration, necrosis and increased cytoplasmic granularity. Similarly in this group spleen showed reticuloendothelial hyperplasia, coagulative necrosis and lymphoid depletion. But the changes in the liver, heart and spleen were less severe in the combination groups. Significantly lower values were observed in group(s) 3 and 4. These changes suggest that Artemisia nilagirica has antimicrobial and hepatoprotective effects. Ultrastructural changes in the group 5 revealed relatively dense population of mitochondria along with abundant endoplasmic reticulum proliferation with no significant nuclear changes, as compared to control (group 6). These changes indicate that methanolic extract of Artemisia nilagirica is not toxic to liver even at the concentration of 2g per litre of water over a period of 18 days.