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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Disposition kinetics and tissue residue study of sulphadiazine-trimethoprim and amprolium in broiler poultry
    (G.B. Pant University of Agriculture and Technology, Pantnagar, District Udham Singh Nagar, Uttarakhand. PIN - 263145, 2022-07) Bisht, Preeti; Ahmad, A. H.
    The present study was undertaken to investigate the pharmacokinetics and tissue residue study of sulphadiazine-trimethoprim ,when given intramuscular (i.m) in a combination (20mg.kg-1 sulphadiazine and 4mg.kg-1 trimethoprim) @ 24.0mg.kg-1 and amprolium given orally @ 30.0mg.kg-1 in poultry following single and multiple (5) dose administration. In the present study Biotrim®, a combination of sulphadiazine-trimethoprim in the ratio of 5:1 (sulphadiazine 400mg and trimethoprim 80mg) was given @24.0mg.kg-1 b.w i.m as a single dose to nine birds and as a multiple dose to nine birds for 5 consecutive days. Amprolium 20% was used and given @30.0mg.kg-1 b.w orally as a single dose to nine birds and as a multiple dose to nine birds for 5 consecutive days. The concentration of sulphadiazine-trimethoprim and amprolium in plasma and tissue of these animals was analysed by HPLC. The initial peak plasma concentration of 24.06 and 1.27μg.ml-1 for sulphadiazine and trimethoprim was detected in poultry following single dose i.m. administration and 0.94μg.ml-1 for amprolium following single dose oral admiministration, respectively. The volume of distribution, clearance, mean area under curve (AUC) and elimination half- life calculated was 0.85L.kg-1, 0.12L.h-1.kg-1, 171.12h.μg.mL-1 and 4.73h and 2.64 L.kg-1,0.43 L.h-1.kg-1, 9.71 h.μg.mL-1and 4.53h for sulphadiazine (SDZ) and trimethoprim (TMP) respectively, following single dose i.m administration of SDZ/TMP combination. For amprolium, the volume of distribution, clearance, mean area under curve (AUC) and elimination half- life following single dose oral administration calculated was 21.941 L.kg-1,14.446 L.h-1.kg-1,2.172 h.μg.mL-1 and 1.027h, respectively. In multiple dose study, volume of distribution, clearance, mean area under curve and elimination half-life calculated for sulphadiazine was 0.81 L.kg-1, 0.11 L.h-1.kg-1,176.41 h.μg.ml-1 and 4.93h after first dose and 0.80 L.kg-1, 0.12L.kg-1, 176.32 h.μg.ml-1 and 4.87 h after last dose, respectively. For TMP volume of distribution, clearance, mean area under curve and elimination half-life calculated as 2.75L.kg-1, 0.49L.h- 1.kg-1,8.72h.μg.ml-1 and 4.22h, respectively, after first dose and 2.81L.kg-1,0.35L.h-1.kg-1,11.70h.μg.ml-1 and 5.73h, respectively after last. For amprolium volume of distribution, clearance, mean area under curve and elimination half-life calculated was 16.731L.kg-1, 14.145L.h-1.kg-1, 2.202h.μg.ml-1 and 0.833±0.061h, respectively after first dose, 0.893L.kg-1,12.647L.h-1.kg-1,2.540h.μg.ml-1and 16.361h, respectively after last dose. According to the results obtained in the pharmacokinetic study an individualized dosage regimen were calculated. An i.m. dosage regimen of sulphadiazine with a priming dose of 43.32 mg.kg-1 and a maintenance dose of 35.25 mg.kg-1 for every 12 hr were estimated to maintain the therapeutic concentration. An i.m. dosage regimen of trimethoprim with a priming dose of 10.0mg.kg-1 followed by a maintenance dose of 8.7 mg.kg-1 at 12 h interval is recommended. For amprolium an oral dosage regimen with a priming dose of 28.4mg.kg-1 followed by a maintenance dose of 28.3 mg.kg-1 recommended. Following single dose i.m administration highest residual concentration of sulphadiazine and trimethoprim were observed in kidney (0.28 μg.g-1 for SDZ and 0.69μg.g-1 for TMP) followed by liver at 24hrs post administration of SDZ/TMP combination. No drug residue was found after 72h of post administration of SDZ/TMP combination. In case of multiple dose i.m administration of SDZ/TMP combination, residue of SDZ and TMP were present in kidney, liver and muscle upto 96hr post administration with highest concentration in kidney (0.78μg.g-1 for sdz and1.19 μg.g-1 for tmp). For amprolium following single dose oral administration residue were found in liver, kidney, muscles with highest concentration found in liver (0.53 μg.g-1) at 24hr post administration. In case of multiple dose oral administration of amprolium, highest concentration found in liver (0.62μg.g-1) at 48hr post administration. Tissue residue were found in liver, kidney and muscles upto 96 hr post administration of amprolium.
  • ThesisItemOpen Access
    Disposition kinetics and tissue residue study of Sulphadiazine-trimethoprim and amprolium in broiler poultry
    (G. B. Pant University of Agriculture and Technology, Pantnagar, 2022-07) Bisht, Preeti; Ahmad, A.H.
    The present study was undertaken to investigate the pharmacokinetics and tissue residue study of sulphadiazine-trimethoprim ,when given intramuscular (i.m) in a combination (20mg.kg-1 sulphadiazine and 4mg.kg-1 trimethoprim) @ 24.0mg.kg-1 and amprolium given orally @ 30.0mg.kg-1 in poultry following single and multiple (5) dose administration. In the present study Biotrim®, a combination of sulphadiazine-trimethoprim in the ratio of 5:1 (sulphadiazine 400mg and trimethoprim 80mg) was given @24.0mg.kg-1 b.w i.m as a single dose to nine birds and as a multiple dose to nine birds for 5 consecutive days. Amprolium 20% was used and given @30.0mg.kg-1 b.w orally as a single dose to nine birds and as a multiple dose to nine birds for 5 consecutive days. The concentration of sulphadiazine-trimethoprim and amprolium in plasma and tissue of these animals was analysed by HPLC. The initial peak plasma concentration of 24.06 and 1.27μg.ml-1 for sulphadiazine and trimethoprim was detected in poultry following single dose i.m. administration and 0.94μg.ml-1 for amprolium following single dose oral admiministration, respectively. The volume of distribution, clearance, mean area under curve (AUC) and elimination half- life calculated was 0.85L.kg-1, 0.12L.h-1.kg-1, 171.12h.μg.mL-1 and 4.73h and 2.64 L.kg-1,0.43 L.h-1.kg-1, 9.71 h.μg.mL-1and 4.53h for sulphadiazine (SDZ) and trimethoprim (TMP) respectively, following single dose i.m administration of SDZ/TMP combination. For amprolium, the volume of distribution, clearance, mean area under curve (AUC) and elimination half- life following single dose oral administration calculated was 21.941 L.kg-1,14.446 L.h-1.kg-1,2.172 h.μg.mL-1 and 1.027h, respectively. In multiple dose study, volume of distribution, clearance, mean area under curve and elimination half-life calculated for sulphadiazine was 0.81 L.kg-1, 0.11 L.h-1.kg-1,176.41 h.μg.ml-1 and 4.93h after first dose and 0.80 L.kg-1, 0.12L.kg-1, 176.32 h.μg.ml-1 and 4.87 h after last dose, respectively. For TMP volume of distribution, clearance, mean area under curve and elimination half-life calculated as 2.75L.kg-1, 0.49L.h- 1.kg-1,8.72h.μg.ml-1 and 4.22h, respectively, after first dose and 2.81L.kg-1,0.35L.h-1.kg-1,11.70h.μg.ml-1 and 5.73h, respectively after last. For amprolium volume of distribution, clearance, mean area under curve and elimination half-life calculated was 16.731L.kg-1, 14.145L.h-1.kg-1, 2.202h.μg.ml-1 and 0.833±0.061h, respectively after first dose, 0.893L.kg-1,12.647L.h-1.kg-1,2.540h.μg.ml-1and 16.361h, respectively after last dose. According to the results obtained in the pharmacokinetic study an individualized dosage regimen were calculated. An i.m. dosage regimen of sulphadiazine with a priming dose of 43.32 mg.kg-1 and a maintenance dose of 35.25 mg.kg-1 for every 12 hr were estimated to maintain the therapeutic concentration. An i.m. dosage regimen of trimethoprim with a priming dose of 10.0mg.kg-1 followed by a maintenance dose of 8.7 mg.kg-1 at 12 h interval is recommended. For amprolium an oral dosage regimen with a priming dose of 28.4mg.kg-1 followed by a maintenance dose of 28.3 mg.kg-1 at 12 h interval is recommended. Following single dose i.m administration highest residual concentration of sulphadiazine and trimethoprim were observed in kidney (0.28 μg.g-1 for SDZ and 0.69μg.g-1 for TMP) followed by liver at 24hrs post administration of SDZ/TMP combination. No drug residue was found after 72h of post administration of SDZ/TMP combination. In case of multiple dose i.m administration of SDZ/TMP combination, residue of SDZ and TMP were present in kidney, liver and muscle upto 96hr post administration with highest concentration in kidney (0.78μg.g-1 for sdz and1.19 μg.g-1 for tmp). For amprolium following single dose oral administration residue were found in liver, kidney, muscles with highest concentration found in liver (0.53 μg.g-1) at 24hr post administration. In case of multiple dose oral administration of amprolium, highest concentration found in liver (0.62μg.g-1) at 48hr post administration. Tissue residue were found in liver, kidney and muscles upto 96 hr post administration of amprolium.