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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Evaluation of therapeutic potential of Cichorium intybus using high-throughput computational and heavy metals intoxicated rat models
    (G. B. Pant University of Agriculture and Technology, Pantnagar, 2022-08) Pathak, Abhishek; Singh, S.P.
    This thesis research work was undertaken to assess the therapeutic potential of Cichorium intybus using high throughput in silico, in vitro phytochemical and antioxidant analysis and in vivo study for lead and nickel induced subchronic toxicity and its amelioration in rats. In silico study revealed that selected phytoconstituents of Cichorium intybus had good oral bioavailability and rutin, cichoric acid, chlorogenic acid, lactopicrin and quercetin had highest binding affinity for CYP3A1 protein. Aqueous extract of Cichorium intybus leaves has highest percent yield followed by hydroethanolic extract (70%). Minerals like Ca+2, Mg+2 and Fe+2 were found in higher concentration than others in chicory leaf powder. Total flavonoid and phenolic content were found in higher concentration in hydroethanolic than aqueous and methanolic extracts of Cichorium intybus leaves. In vitro evaluation of antioxidant property of different extracts by DPPH, ABTS and nitric oxide free radical scavenging assay showed that hydroethanolic extract of Cichorium intybus leaves (HECL) had minimum IC50 value and highest antioxidant property as compared to aqueous and methanolic extracts. For in vivo study, forty two male Wistar rats were divided equally and randomly into seven groups. Group I served as control and other groups were given orally lead @ 50 mg/kg b wt in group II, nickel @ 40 mg/kg b wt in group III, lead @ 50 mg/kg b wt + nickel @ 40 mg/kg b wt in group IV, lead @ 50 mg/kg b wt + HECL @ 250 mg/kg b wt in group V, nickel @ 40 mg/kg b wt + HECL @ 250 mg/kg b wt in group VI, lead @ 50 mg/kg b wt + nickel @ 40 mg/kg b wt + HECL @ 250 mg/kg b wt in group VII, respectively, daily for 90 days. A significant (p<0.05) reduction was observed in body weight and feed intake while mild to moderate changes in absolute organ weight in lead and nickel alone and in combination exposed rats whereas, HECL treatments did not show any significant changes in body weight and feed intake. A significant (p<0.05) reduction in TEC, TLC, Hb, PCV and platelet counts was observed in lead and nickel alone and combined groups whereas a significant (p<0.05) improvement in TEC, TLC, Hb, PCV and platelet count was observed after treatment with HECL. A significant (p<0.05) increase in serum lipid profile and serum ALT, AST, ALP, LDH and GGT activities while HDL was found to be decreased in lead and nickel alone and combined groups, however, these values were ameliorated in HECL treated groups. Serum creatinine and BUN level were increased significantly (p<0.05) in lead and nickel exposed rats while combined group showed more increase in concentration of these parameters which were significantly (p<0.05) restored by the HECL treatment. A significant (p<0.05) increase in erythrocyte and tissue lipid peroxidation was observed while decrease in GSH content, SOD, CAT, GPx and GST activities in lead and nickel alone and in combination groups whereas a significant (p<0.05) improvement was observed in these parameters following simultaneous medication with HECL for 90 days. Exposure to lead and nickel alone and in combination induced DNA fragmentation in liver whereas treatment with HECL showed partial improvement. mRNA expression of CYP3A1 gene significantly (p<0.05) inhibited in lead and nickel alone and in combination groups whereas treatment with HECL significantly (p<0.05) restored mRNA expression of CYP3A1 gene in lead and nickel alone groups. Testicular injury biomarkers (LDH and GGT) activities were significantly (p<0.05) increased. A significant (p<0.05) decrease in live sperm percent, sperm motility and sperm count while increase in dead sperm percentage, HOST positive sperm and total number of abnormal sperms due to lead and nickel toxicity and combined group showed reproductive toxicity whereas HECL significantly (p<0.05) restored these parameters toward normalcy in lead and nickel alone treatment groups. Testicular injury biomarker (LDH and GGT) activity was significantly (p<0.05) increased in lead, nickel alone and combined exposed groups whereas HECL significantly (p<0.05) restored these enzyme activities. Histopathology changes in liver, kidney and testes and ultrastructure changes in liver by lead and nickel were also reversed by treatment with HECL. It is concluded from this investigation that HECL @ 250 mg/kg b wt reversed lead and nickel orally administered @ 50 and 40 mg/kg b wt alone and in combination, induced haemotoxic, hepatotoxic, nephrotoxic, alteration of drug metabolizing enzyme gene expression and reproductive toxic effect in a 90 days study in rats.