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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Ameliorating potential of Trianthema portulacastrum Linn. and Chenopodium album Linn. in 7,12-dimethylbenz(a) anthracene induced mammary tumour in wistar rats
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2016-07) Nirbhay Kumar; Ahmad, A.H.
    Evaluation of ameliorating potential in terms of anticancerous and antioxidant properties of aerial parts of Trianthema portulacastrum and Chenopodium album was conducted in DMBA induced mammary tumorigenesis model in Wistar rats. The results of the quantitative phytochemical analysis of different extracts of both the plants revealed the presence of alkaloids, flavonoids, saponins, phenolic compounds, reducing sugars, glycosides, proteins, fixed oils and fat. Total phenolics and flavonoids in various extracts of T. portulacastrum and C. album revealed maximum content in the hydroethanolic extract. The DPPH and ABTS radical scavenging assays for different extracts were also found to be highest in the hydroethanolic extract. In vitro studies in HeLa cell lines revealed better cytotoxicities and apoptotic effects in the hydroethanolic and hydromethanolic extracts for both the plants. Based on the findings of in vitro studies, the hydroethanolic extracts of T. portulacastrum and C. album were selected for in vivo studies. High doses of T. portulacastrum were found to be toxic in rats. The mammary tumours were induced in animals by oral administration of DMBA in two divided doses @ 50 and 30 mg/kg at an interval of one week. The curative anticancer study was done in DMBA induced mammary tumour bearing animals by giving two doses of 200 and 400 mg/kg of hydroethanolic extracts of T. portulacastrum (TPHE) and C. album (CAHE) for 30 days. The parameters evaluated included clinical, haematological and serum biochemical; oxidative stress related parameters like lipid peroxidation, GSH, catalase, SOD, and glutathione reductase; mRNA expression studies for apoptosis related genes like caspase-3, Bcl-2, IL-10 and TNF-α; flow cytometry studies involving mitochondrial transmembrane potential and annexin V and propidium iodide was done for detecting percentage of apoptotic cells. The results revealed that TPHE and CAHE extracts were able to counteract the DMBA induced carcinogenesis. Comparatively, better curative anticancer activity was shown by TPHE 400 treated animals. The antioxidant status of TPHE 400 treated group was also found to be better than other groups. The protective study for evaluating the ability of these two extracts in preventing the development of mammary tumours was conducted by giving TPHE and CAHE extracts @ 200 mg/kg along with DMBA (50 and 30 mg/kg at interval of one week) treatment for 60 days. The results revealed that T. portulacastrum was having a comparatively better cancer preventing ability than C. album. Thus, it can be concluded from the present study that hydroethanolic extracts of T. portulacastrum and C. album has ameliorating potential against DMBA induced carcinogenesis.
  • ThesisItemOpen Access
    Evaluation of anticancer and antioxidant effects of Melia azerdarach and Cuminum cyminum in Wistar rats
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2016-04) Anu Gopal; Ahmad, A.H.