Loading...
Thumbnail Image

Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

Browse

Search Results

Now showing 1 - 1 of 1
  • ThesisItemOpen Access
    Immunopathology of calcium nanoparticles in Wistar rats
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-07) Kandpal, Diksha; Chauhan, R.S.
    The present experimental study was conducted in Wistar rats for 90 days for evaluating immunopathological effect of calcium nanoparticles. The rats were administered nanocalcium at NOAEL dose rate of 1000mg/kg b.wt. The experimental rats were keenly observed for presence of clinical signs and behavior. However, no alterations were recorded. The clinico-pathological parameters of the present study such as hemoglobin showed no alteration. Total leucocyte count (TLC), lymphocytes count and Absolute lymphocyte count (ALC) was found to decrease in nanocalcium treated rats. The decrease might be attributed to the lymphocytotoxic action of nanocalcium leading to lymphocytopenia and leucopenia. Neutrophil count and absolute neutrophil count (ANC) was found to increase and the increase; may be attributed to their compensatory increase against the lymphocytes in nanocalcium treated rats. Serum total protein, serum albumin and serum globulin was found to decrease whereas; serum gamma globulin was increased. The increase or decrease in protein levels may be due to the inflammatory conditions induce by nanoparticles administration. Serum creatinine and serum calcium were increased, although slight, may pose a serious chronic kidney disease risk in long run. Serum cholesterol and serum ALT were increased. Increased serum ALT increases serum cholesterol and thus calcium nanoparticles over a long durationpossess a threat for subsequent development of atherogenesis. Lymphocyte stimulation assay was performed and was found to decrease for all the mitogens used. Thus, immunotoxic effect of calcium nanoparticles on CMI and HMI was evident. The delayed type hypersensitivity was examined using DNFB and results were suggestive of manifestations of CMI which can be considered as to be down regulated due to nanocalcium. Histopathologically, there were areas of coagulative necrosis, vacuolar degeneration and infiltration of inflammatory cells in liver. Kidneys showed hemorrhages and congestion, atrophy of glomeruli, degenerative and necrotic changes of the kidney tubular epithelium. Spleen revealed wide areas of hemosiderosis, lymphoid depletion and increase in the red pulp region. In lungs emphysema, increased interalveolar septa, infiltration of mononuclear cells was present. Intestines revealed mild lesions of catarrhal enteritis. In heart, congestion and necrosis of the myofibers in were recorded. TEM showed degeneration and swelling of the mitochondria with loss of cristae along with rough endoplasmic reticulum (rER) degeneration with areas of electron dense particles in hepatocytes and kidney. TEM for kidney also recorded thickening of the basal lamina of the kidney tubule. TEM of spleen showed phagocytic process of various leucocytes with electron dense particles. The nanoparticles work through mechanism of protein corona and reactive oxygen species formation. These mechanisms assist nanoparticles to increase their circulation time in the living system and subsequently accompany the changes. Calcium being the component of the living system is degradable and less inflammatory and thus finds its usage more as compare to other nanoparticles. Present study however of short duration had recorded the ill effect of calcium nanoparticles on NOAEL dose. This paves the way for conducting a study on large number of animals for longer duration to further conclude the potential immunotoxic, hepatotoxic, nephrotoxic and other effects of calcium nanoparticles.