Thumbnail Image

Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

Browse

20211
Reset filters
Subject: Veterinary Gynaecology and Obstetrics × Author: Arya, Damini × End date: 2022 × Start date: 2020 × Type: Thesis ×
Reset filters

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    ThesisItemOpen Access
    In silico studies on efficacy of various antibacterial drugs against bovine endometritis
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2021-09) Arya, Damini; Sharma, Mridula
    The present study was conducted with the objective to find effective drug against bacterial bovine endometritis using Molecular docking. The antibacterial property of selected plants (already studied in vivo and new) was studied its comparison with conventional antibiotics was done. The plants selected for study were Tulsi, Garlic, Aloe vera and Kalmegh, among them Tulsi and Garlic were previously studied in vivo and in vitro for treating bovine endometritis and Aloe vera and Kalmegh were selected on the basis of its potent antibacterial activity. The phytochemicals of Tulsi were thymol, eugenol, linalool, carvacrol, apigenin and caryophyllene. Phytochemicals of Garlic were allicin, ajoene, diallyldisulphide and diallyltrisulphide. Phytochemicals of Aloe vera were aloe-emodin, anthracene, campesterol, lupeol and sitosterol β. Phytochemicals of Kalmegh were andrographolide, 14-deoxyandrographolide, neoandrographolide and 3-O-β-D-Glucopyranosyl-14,19-Dideoxyandrographolide. Selection of bacteria (S. aureus and E. coli) for the present study was done on the basis of most predominantly found bacteria causing bovine endometritis as observed in previous studies. From S. aureus Gyrase B, DNA ligase, dehydrosqualene synthase and FtsA protein and from E. coli DNA gyrase, FtsZ and ZapD protein were selected. The selected bacterial proteins were docked against phytochemicals of plants. To conduct molecular docking the 3-D structure of receptors and ligands is needed. The structures of receptor or bacterial proteins were obtained from Protein Data Bank in PDB format. The 3-D structures of ligand were retrieved from PubChem and ChemSpider databases in SDF and Jsmol format respectively. Based on molecular docking it was concluded that, Aloe vera showed highest binding affinity followed by Kalmegh, Tulsi and Garlic i.e., -8.05, -7.55, -6.40 and -3.89 Kcal/mol respectively. When the antibacterial property of plants and antibiotics were compared it was concluded that the Aloe vera and Kalmegh showed higher binding affinity as compared to gentamicin (-6.95 Kcal/mol) and enrofloxacin (-6.97 Kcal/mol) against pathogenic proteins of Staphylococcus aureus and E. coli. On comparing binding energy obtained by each phytochemical of each plant it was observed that Apigenin of Tulsi, Ajoene of Garlic, Lupeol of Aloe vera and 3-O-β-D-Glucopyranosyl-14,19- Dideoxyandrographolide of Kalmegh showed the better efficacy as they had minimum binding energy against all / maximum bacterial proteins as compared to other phytochemicals of the respective plant. Thus, the combination therapy of Aloe vera, Tulsi and Kalmegh or the specific most efficient phytochemicals (Apigenin, Lupeol, sitosterol β, Anthracene, Neoandrographolide and 3-O-β-DGlucopyranosyl-14, 19-Dideoxyandrographolide) combination may be used for further in vivo or in vitro trials in a direction of effective drug discovery against bacterial bovine endometritis.