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Kerala Veterinary and Animal Sciences University, Wayanad

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20011
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Subject: Epidemiology × Author: BIPIN., K. C. × Type: Thesis ×
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    ThesisItemOpen Access
    SEROCONVERSION OF THREE DIFFERENT FOOT-AND-MOUTH DISEASE VACCINES IN CATTLE
    (COLLEGE OF VETERINARY AND ANIMAL SCIENCES Mannuthy - Thrissur, 2001-04-11) BIPIN., K. C.; Tresamol, P.V.
    Seroconversion of three different commercial inactivated quadrivalent Foot-and-Mouth disease vaccines were studied. One aluminium hydroxide gel vaccine and two oil-adjuvanted vaccines were used for the study in three groups of cattle. Monthly assessment of antibody titres against O, A, C and Asia-1 antigens were made by liquid phase blocking-ELISA (LPB-ELISA). Unvaccinated calves of four months and above age were grouped into three and vaccinations were made as per manufacturer's regime. Group I and group II animals did not showed significant difference m type O antibody titres throughout the study period except following booster vaccination of group I in seventh month. Both groups mamtained protective titres except in the fourth and fifth months of study. Group III showed a lower level of antibody titres throughout the study period. Protective type A antibody titres were maintained by group I and group II animals during the entire study period except in the fifth month. No significant difference between these two groups observed except following the second booster vaccination in group II. Group III showed comparatively lower antibody titres against type A FMD antigen. All the three groups showed protective mean type C antibody titres throughout the study period. But group III showed an antibody titre below protective level during fourth month. Group I and group II did not show significant variation in antibody titres except following respective booster vaccinations. Group I and group II maintained a protective level of type Asiarl antibody titres except during fifth month. Group III showed significantly low Asia-1 antibody titres throughout the study period. The booster vaccinations produced anamnestic response in group I and group II in almost all cases. Group III animals showed lower antibody titres against all the four virus types when compared to group I and group II and response to booster vaccinations were poor m group III. Comparison between the three vaccines in terms of cost required for immunising a single ammal for the first one year revealed that oil-adjuvanted vaccine II required the lowest cost while oil-adjuvanted vaccine III required the highest cost for the first one year.