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Kerala Veterinary and Animal Sciences University, Wayanad

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20171
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Subject: Epidemiology × Author: AARSHA, RAJ × End date: 2017 × Start date: 2010 × Type: Thesis ×
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    ThesisItemOpen Access
    ACUTE PHASE PROTEINS IN SERUM AND MILK AS DIAGNOSTIC TOOLS IN BOVINE SUBCLINICAL MASTITIS
    (COLLEGE OF VETERINARY AND ANIMAL SCIENCES-MANNUTHY,THRISSUR, 2017) AARSHA, RAJ; .Vinodkumar, .K
    This study aimed to evaluate the utility of acute phase proteins (APP) levels in the serum and milk as diagnostic markers for subclinical mastitis in dairy cattle. The concentrations of various acute phase proteins (APP) like Haptoglobin (Hp), C- reactive protein (CRP), α- 1 acid glycoprotein (AGP) and albumin in milk as well as Hp,serum amyloid A (SAA), CRP and albumin in serum of 40 normal cows as well as 40 subclinically infected cows were compared in the study. The milking animals were screened by California mastitis test (CMT), electrical conductivity, somatic cell count (SCC) and bacterial culture and isolation. Comparison was also made between the variations of APP levels based on the CMT, EC and SCC scores as well as the correlation with lactoferrin (Lf) levels in milk. The pathogen specific variations in the APP values were also investigated. The values of Hp, SAA and AGP showed significant difference between the groups of normal and subclinically affected cows. On comparing the means based on CMT scores, Hp and AGP values in milk were significantly different between groups. Hp, CRP and AGP in milk showed significant difference between groups when compared based on EC values. The cows with different SCC ranges showed significant changes in case of Hp and AGP in milk. Hp in milk and SAA showed positive correlation with Lf. There was no significant difference noticed in the APP values of cows with single and mixed infections. The study showed that the use of APP like Hp and AGP in milk very effective for the early diagnosis of subclinical mastitis in bovines. The APP in serum can be altered by any other factors making it non specific whereas in milk the APP values will increase only in case of mammary gland inflammation and hence is of high diagnostic significance.