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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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Subject: Veterinary Pharmacology × End date: 1999 × Start date: 1990 × Type: Thesis × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    STUDIES ON THE PHARMACOKINETICS AND BIOTRANSFORMATION OF FENBENDAZOLE AND TRICLABENDAZOLE IN CALVES
    (AAU, Anand, 1994) Roy, Dulal Chandra; Malik, J. K.
    In the present study, detailed pharmacokinetics and biotransformation of FBZ were investigated in healthy buffalo calves and those fed different diets or subclinically infected with nematode parasites. The detailed pharmacokinetics and biotransformation studies of the drugs were carried out in buffalo calves and cow calves after administration of TCBZ and in buffalo calves following co-administration of FBZ with TCBZ. In addition, the influence of diet on the pharmacokinetic behaviour of TCBZ metabolites was investigated in cow calves. Following FBZ administration or ingestion, FBZ, OFZ and FBZSO2 were detected in plasma of buffalo calves. After intraruminal administration of FBZ (7.5 mg.kg-1), the pharmacokinetics of FBZ and its metabolites were best described by a one-compartment open model in subclinically infected and healthy buffalo calves fed different diets.
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    ThesisItemOpen Access
    STUDIES ON THE EFFECT OF INDUCED THEILERIOSIS (Theileria annulata) AND ENDOTOXAEMIA (Escherichia coli) ON THE PHARMACOKINETICS OF OXYTETRACYCLINE IN CALVES
    (AAU, Anand, 1994) Kumar, Rajiv; Malik, J. K.
    In the present study, detailed pharmacokinetics of conventional and long-acting formulations of oxytetracycline were investigated in healthy calves and those infected with T. annulata or given E. coli endotoxin. In addition, clinical, haematological and biochemical effects of T. annulata infection and endotoxaemia and the ability of two different formulations of OTC in reversing the effects induced by the former were thoroughly investigated in cow calves. Theilerioss was induced in calves by subcutaneous administration of ground-up stabilate equivalent to 30 adult ticks (Hyalomma anatolicum anatoUcum) infected with T. annulata. Theileriosis produced an 'acute phase response in calves which was characterized by fever, enlargement of superficial lymph nodes, parasitaemia, anaemia, leucopenia, lymphopenia, hypoglycaemia, hopocholesterolaemia, hypoproteinaemia, bilirubinaemia, azotaemia, hypokalaemia, hyponatraemia, hypocalcaemia, hypophosphataemia, hypozincaemia, hypoferraemia, hypocupraemia, hypomanganesaemia and diminished activity of serum alkaline phosphatase. Conversely, the activities of lactate dehydrogenase, acid phosphatase and aspartate aminotransferase and alanine aminotransferase in serum were significantly elevated. T. annulata infection produced significant alterations in the pharmacokinetic behaviour of OTC administered to calves either by intravenous or intramuscular route. As compared to normal animals, lower levels of OTC were generally estimated in serum of infected calves. In healthy and T. annulata Infected calves the disposition kinetics of OTC was best described by two and one-compartment open models following intravenous and intramuscular administration of conventional and long-acting formulations of oxytetracycline.