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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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Subject: Veterinary Pharmacology × Author: GOHIL, PRADHYUMAN VARSlNHBHAI × End date: 2007 × Start date: 2004 × Type: Thesis ×
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    ThesisItemOpen Access
    STUDIES ON CEFTRIAXONE PHARMACOKINETICS FOLLOWING INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN BUFFALO CALVES
    (AAU, Anand, 2004) GOHIL, PRADHYUMAN VARSlNHBHAI; Thaker, A. M.
    Ceftriaxone, a broad spectrum semisynthetic third generation cephalosporin has excellent activity against gram negative bacteria as well as wide range of gram positive bacteria and some anaerobic bacteria, including enterobacteriaceae and many strain oipseudomonas aeruginosa. The present study was conducted to determine the pharmacokinetics of ceftriaxone after single dose intravenous and intramuscular administration in Surti buffalo calves. The ceftriaxone concentration in plasma was determined by High Performance Liquid Chromatography (HPLC). Following single dose (10 mg/kg of body weight) intravenous administration of ceftriaxone, the therapeutically effective plasma drug concentration (> 0.25 µg ml-1) was maintained for up to 8 hours. Pharmacokinetics of the drug was best described by two-compartment open model following intravenous administration. The drug was rapidly distributed [t1/2α: 0.09 ± 0.01 h; Vd (area); 0.48 ± 0.05 L kg-1] and eliminated (t1/2β: 1.27 ± 0.04 h) from the body with a clearance rate of 4.40 ± 0.44 ml min-1 kg-1. Following single dose intramuscular administration of ceftriaxone at the rate of 10 mg/kg of body weight in buffalo calves, the therapeutically effective plasma drug concentration was detectable at 0.033 hours (2 minutes) and maintained for 12 hours. Peak plasma concentration (15.75 ± 2.39 µgml-1) was obtained at 0.5 hours after intramuscular administration. The drug is rapidly absorbed from the site of injection (t1/2ka: 0.35 ± 0.01 hours), widely distributed [Vd(area); 1.53 ± 0.2] L kg-1 and slowly eliminated from the body (t1/2β: 4.38 ± 0.4 hours). The bioavailability of ceftriaxone was 0.70 ± 0.2 (70.2 ± 2.0 per cent) following intramuscular injection.The studies indicate that a satisfactory intravenous dosage regimen of ceftriaxone in calves would be 13.23 mg/kg of body weight given at 12 hour interval. However, ceftriaxone can also be given intramuscularly in calves at the rate of 10 mg/kg of body weight repeated at 12 hour interval. A more practical approach would be to administer intravenous loading dose (13.0 mg/kg of body weight) followed by intramuscular maintenance dose (10 mg/kg of body weight) repeated at 12 hour interval. The recommended doses need to be evaluated in clinical situations to establish its therapeutic efficacy.