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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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Subject: Veterinary Pathology × Author: BHAJANTRI, BASAVARAJ S × End date: 2009 × Start date: 2000 ×
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    ThesisItemOpen Access
    STUDY ON PATHOGENICITY OF DICLOFENAC SODIUM ON SWISS ALBINO MICE (Mus musculus)
    (AAU, Anand, 2009) BHAJANTRI, BASAVARAJ S; Prajapati, K. S.
    The present research work was conducted on 24 male and 24 female Swiss albino mice to study the repeated dose toxicity of Diclofenac sodium. Animals were randomly divided into 4 different groups with six male and six female in each. Group I severed as control. Group II, III and IV were administered with 2.37, 4.75 and 9.5 mg/kg of Diclofenac sodium per kg body weight respectively once daily for 28 days. The animals were monitored for any observable toxic symptoms and mortality throughout the experimental period. All the animals were weighed weekly to monitor body weight gain. The food consumption was also measured once a week. After completion of 28 days treatment, blood samples were collected for haematology and serum biochemical analysis. Necropsy was performed in all sacrificed animals and gross lesions were recorded. Tissue samples were collected in 10% formalin solution for histopathological examination. The extent and severity of observed symptoms varied according to the dosage administered to animals. Symptoms like dullness, depression, lethargy, and rough hair coat were noticed in mice of group III and FV. The dose dependent reduction in body weight and feed consumption was observed in animals of mid and high dose group. There was significant reduction in the red blood corpuscles, packed cell volume, haemoglobin and mean corpuscular haemoglobin concentration, where as significant increase in mean corpuscular volume and absolute neutrophils in animals of group III and IV. Differential leucocyte count revealed significant increase in neutrophil and decrease in lymphocyte count in animals of Diclofenac sodium treated groups in and IV. In treatment group III and IV, the AST, ALT and Total bilirubin values were significantly increased. Where as significant decrease in total protein, albumin, globulin, and cholesterol was noticed. There was significant increase in urea, creatinine and uric acid in group in and IV. The animals of group IV revealed significant decrease in absolute organ weights of liver, kidneys and there was increase in absolute weight of spleen. Gross pathological changes were characterized by congestion and hemorrhages in intestine and stomach. Enlargement of spleen was the common findings in the animals of group in and IV. Varying degrees of degeneration was noticed in histopathological sections of liver and kidney. There were erosions, ulceration and necrosis of mucosal epithelium of stomach and intestine. Spleen showed hyperplasia of RE cells while lung showed mild congestion and edema in animals of group III and group FV. Gross and microscopic lesions were indicative of gastrointestinal and renal toxicity. The results of the present study indicated toxic potential of Diclofenac sodium, if used for longer time in animals.