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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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20011
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Subject: Veterinary Pathology × Author: A D, Deshmukh × Start date: 1980 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON INFECTIOUS BURSAL DISEASE VIRUS INDUCED IMMUNOSUPPRESSION AND ITS EFFECT ON LYMPHOID ORGANS IN LAYER CHICKS
    (AAU, Anand, 2001) A D, Deshmukh; Joshi, B. P.
    The present study was undertaken to evaluate IBDV induced immunosuppressive effect on different lymphoid organs i.e. bursa of Fabricius, spleen, thymus, caecal tonsils and gland of Harder in layer chicks. A primary survey in relation to autopsy incidence of the disease was also undertaken from the available data on poultry autopsies from January 1996 to December 2000 to ascertain the severity and importance of the disease condition. The relative incidence of infectious bursal disease (IBD) was found to be 9.74 per cent with yearwise frequency varying from 7.70 to 12.39 per cent. Majority of these cases (70.7%) were recorded during summer months (March to July). The mortality was recorded in the age group of 2nd to 16th week with peak incidence between fourth to ninth week of age. Among different breeds of layer birds the frequency of the disease was found to be highest in Babcock layers followed by Bovans, Rhode Island Red (RIR) and Lohman. Experimental induction of IBDV induced immunosuppression was carried out by procuring 140, day-old White Leghorn Babcock layer chicks and after dividing them into two equal groups as-control and infected on 14th day of age. The infected group of birds were inoculated witli bursal homogenate prepared from natural outbreaks of infectious bursal disease. Ten birds from each group were sacrificed at each weekly interval for the period of five weeks (7 to 35 day PI) and detailed study was made for the evaluation for set parameters. Experimental IBDV Infection resulted in significant rise in IBD ELISA antibody titres and significant fall in NDHI titres at each PI interval upto 35 day PI. The serological response to NDV vaccination was found to be reduced at each PI interval. Boosting with LaSota vaccination on 28* day of birds age (14 day PI) could not result in improvement of titres. There was significant reduction in bursa : body weight ratio (BF:BW) at 14, 21, 28 and 35 day PI and no alteration in spleen body weight (S:BW), thymus body weight (T:BW) and gland of Harder : body weight (GH:BW) at any post-infection interval. Total leukocyte count fall significantly while differential leukocyte count showed significant rise in heterophils and significant fall in lymphocytes throughout the period of experiment. Clinical signs of mild dullness, depression, ruffled feathers and white diarrhoea along with twelve per cent mortality was noticed during acute phase of the first week post-infection period. Gross lesions were confined to BF and marked by reduction in its size to its pronounced atrophy with the advancement of age. Histopathological changes in the BF were progressive in nature. The lesions became severe and more marked with progression of the experiment. At 7 day PI, mild to moderate depletion of lymphoid cells, cystic spaces in the bursal follicles giving moth eaten appearance and interfollicular heterophilic and mononuclear cells infiltration were the prominent lesions. The lesions were more marked at 14 day PI with diffuse necrosis of bursal follicles, hyperplasia and hypertrophy of corticomedullary epithelium and extensive fibrous tissue proliferation. In subsequent post-inoculation interval of 21 and 28 day PI, the lesions became still severe with extreme small size of follicles, cystic dilatation of mucosal epithelium and extensive fibroplasia. On 35 day PI bursal lesions were marked by extensive fibrous tissue proliferation, extreme small sized follicles, and glandular pattern formed by proliferation of mucosal lining epithelium. Few of the bursal follicles were seen regenerated during this stage in some of the birds. Mild lesions in the form of mild depletion of lymphocytes and RE cell hyperplasia were observed in spieenic parenchyma and caecal tonsils at 7 and 14 day PI. Gland of Harder showed depletion of lymphoid cell and plasma cell population compared to the control birds at 21, 28 and 35 day PI. The fields IBDV isolate resulted in its transmissibility by inducing immunosuppression