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Theses

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2018 - 20192
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Subject: Chemistry × Author: Suman × Start date: 2003 × Type: Thesis × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    Synthesis of bioactive heterocyclic compounds using green synthetic methods and their bioevaluation
    (CCSHAU, 2019) Suman; Rajvir Singh
    Green chemistry is a sustainable approach to explain latest research topics and expresses an area of scientific discoveries about pollution awareness. Green chemistry is the future chemistry which is simple, efficient and benign in all steps of particular synthesis processes. Coumarins, chalcones, Pyrazoles and Imidazoles are versatile classes of heterocycles and intermediates for the preparation of other organic compounds due to their effective biological activities. For the preparation of these compounds and their derivatives, different organic solvents and reagents are being used which are quite hazardous to environment and human health due to their volatile and toxic nature. Since last few years attempts are being made for ecofriendly synthesis viz. biocatalysis and synthesis by using green catalyst. Biocatalyst is a magical intermediate which is helpful to overcome the negative environmental effects due to various hazardous and toxic chemicals used in synthetic pathways.Therefore an attempt has been made to synthesize above mentioned classes of compounds by using various green catalyst. Thesecompounds were characterized by spectroscopic technique viz.1HNMR, IR, Elemental analysis and other analytical data. The green catalysts were examined by SEM. Synthesized compounds were screened for their antifungal, herbicidal and antioxidant activities at four different concentrations. Compounds 12 and 10 were found more activeagainst the tested fungi Rhizoctonia solani and Aspergillus niger which have EC50values75.03 and 77.53μg/ml respectively. Compounds 11 and 60 were found more active against Raphanus sativus L. (root) and (shoot) exhibited growth inhibition 82.86, 91.66, 92.12, 97.05% and 43.81, 58.00, 67.01, 89.07% respectively at50, 100, 150, 200μg/ml all concentrations.Compound 84 was found most active with least IC50 36.30μg/ml and showed highest DPPH free radical scavenging capacity at 25, 50, 75, 100μg/ml.
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    ThesisItemOpen Access
    Studies on chemical constituents of Prosopis cineraria (L.) and interaction of phenolics with protein
    (CCSHAU, 2018) Suman; Rajvir Singh
    Prosopis cineraria (L.) Druce is native species of Indian desert, mainly known as “King of Desert”. Its all parts have various parmaceutical and medicinal importance. Plant materials i.e. bark, flowers, leaves and pods of Prosopis cineraria were collected and extracted with hot methanol by refluxing method. The respective extractives were divided into two parts. One major part was subjected to column chromatography which affored a total twenty-two compounds. Bark column contained four compounds namely, 24- methylenecycloartan-3-one, Lupeol, 5,7,4‟-trihydroxy-3‟-methoxy flavanone and β- Sitosterol while six compunds namely, Hexacosane, Tetracosyl tetracosanoate, 1- triacontanol, Patuletin, Bis (cis-13-docosenamido) methane and β- Sitosterol from flowers of P.cineraria. leaves afforded eight compounds namely, 1- Heptacosanol, 1- Nonadecanol, Stigmasterol, nonacosane-15-one, 1- tetracosanoic acid, β- Sitosterol, 3-O-methoxy-D-Glucose and 13- docosenamide. Four compounds namely, 1-heptatricontanol, 3,8,8-trimethoxy-3-piperidyl- 2,2‟binaphthalene-1,1‟,4,4‟-tetrone, β- Sitosterol and Catechin were isolated from pods of Prosopis cineraria. Various phytochemical activities like total phenolic content, total flavonoids, mineral contents and phenolics interaction with protein were evaluated from methanolic extract and their fractions. Total phenolic contents were found to be maximum in methanol fraction of pods of Prosopis cineraria while acetone fraction of pods contained maximum total flavonoid content. P. cineraria possessed mineral content in trend of N> P> K> Fe> Cu> Zn> Mn. Acetone fraction of pods part was found to be maximum protein binding capacity at highest concentraction (10μg/μl). It was significantly showed that P. cineraria has nutritionl and digestible value of various fractions by stepwise increased in the percentage activity at different concentrations.