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2005 - 200912010 - 20131
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Subject: Chemistry × Author: Anil Kumar × Start date: 2005 × Type: Thesis ×
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    ThesisItemOpen Access
    Synthesis, characteriztation and bioevaluation of potential agrochemicals
    (CCSHAU, 2013) Anil Kumar; Rajvir Singh
    Heterocyclic systems find wide variety of application in agrochemicals and pharmaceuticals industries. Different organic compounds like, chalcones, coumarins, pyrazoles, isoxazoles and many other heterocyclic compounds containing functionalized nitrogen and oxygen play a predominant role in agrochemicals/pesticide chemistry. They have shown versatile biological activities and have been intensively used as scaffolds for pesticide development. Keeping all this in mind synthesis of 4-[(substituted phenyl-/phenoxy) anilinomethyl-/methyl]-2H-1-naphthopyran-2-ones, 1-[4-(substituted phenyl)-3-(substituted phenyl) prop-2-en-1-ones, 2-(substituted phenoxy)-1-(substituted phenyl) ethanones, pyrazoles, isoproterenol and flavanoids have been carried out. The synthesized compounds were characterized by 1HNMR, IR and other physical and analytical data. Compounds were evaluated for their antifungal and antibacterial activity against A. awamori and S.rolfsii and Bacillus by poisoned food technique and zone inhibition method respectively. Compounds were tested at 10μg/ml, 50 μg/ml, 100 μg/ml and 200 μg/ml. Various compounds of different series exhibited very significant antifungal and antibacterial activity. It was evident from structure activity relationship (SAR) that chloro substituent at different positions in different series of compounds showed the highest toxicity and replacement of chlorine with other functionality like methyl, methoxy bromine decrease the activity significantly. The compounds found acetone needs further exploration for their possible use as agrochemicals.
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    ThesisItemOpen Access
    Chemical investigations of capparis decidua edgew fruits
    (CCSHAU, 2005) Anil Kumar; Dhindsa, Kuldip Singh
    Capparis decidua is one of the twenty six species of the genus Capparis. It is found under dry conditions. The genus is known for a large number of physiologically active constituents and edible quality of the fruit. The present work was aimed at isolating and identifying the various chemical components present in the fruit of Capparis decidua because the fruit of this plant has not been studied so far. In order to achieve the objective, the fruits of Capparis decidua were procured from village Dhamana, district Hisar. The fruits were crushed and the powered material was refluxed in methanol on a water bath. The methanol extract was concentrated at atmospheric pressure when a dark yellow viscous liquid was obtained. It was mixed with silica gel and subjected to column chromatography to isolate the compounds. Two new compounds namely 14-Hydroxytetradec-12-enylbutanoate and stigmastan-4-one were isolated. The isolated compounds were characterized on the basis of IR, 1H NMR and Mass spectral data.