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ThesisItem Open Access Synthesis, characteriztation and bioevaluation of potential agrochemicals(CCSHAU, 2013) Anil Kumar; Rajvir SinghHeterocyclic systems find wide variety of application in agrochemicals and pharmaceuticals industries. Different organic compounds like, chalcones, coumarins, pyrazoles, isoxazoles and many other heterocyclic compounds containing functionalized nitrogen and oxygen play a predominant role in agrochemicals/pesticide chemistry. They have shown versatile biological activities and have been intensively used as scaffolds for pesticide development. Keeping all this in mind synthesis of 4-[(substituted phenyl-/phenoxy) anilinomethyl-/methyl]-2H-1-naphthopyran-2-ones, 1-[4-(substituted phenyl)-3-(substituted phenyl) prop-2-en-1-ones, 2-(substituted phenoxy)-1-(substituted phenyl) ethanones, pyrazoles, isoproterenol and flavanoids have been carried out. The synthesized compounds were characterized by 1HNMR, IR and other physical and analytical data. Compounds were evaluated for their antifungal and antibacterial activity against A. awamori and S.rolfsii and Bacillus by poisoned food technique and zone inhibition method respectively. Compounds were tested at 10μg/ml, 50 μg/ml, 100 μg/ml and 200 μg/ml. Various compounds of different series exhibited very significant antifungal and antibacterial activity. It was evident from structure activity relationship (SAR) that chloro substituent at different positions in different series of compounds showed the highest toxicity and replacement of chlorine with other functionality like methyl, methoxy bromine decrease the activity significantly. The compounds found acetone needs further exploration for their possible use as agrochemicals.