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20171
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Subject: Veterinary Surgery and Radiology × Author: SARMA, BIRAJ KUMAR × End date: 2017 × Type: Thesis × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    ROMIFIDINE, ROMIFIDINE-KETAMINE AND ITS REVERSAL WITH ATIPAMEZOLE IN BOVINE
    (Assam Agricultural University, Khanapara, Guwahati, 2017-01) SARMA, BIRAJ KUMAR; Sarma, Bhupen
    Twenty four clinically affected bovine calves of either sex, weighing 100-150kgs were divided into four groups, containing of 6 calves in each group, where group-I received romifidine @ 20 µg/kg i.m., group-II received romifidine @ 40 µg/kg i.m., group-III received romifidine-ketamine (40µg/kg+2mg/kg) i.m., group-IV received atipamezole @ 40 µg/kg, i.V at 30 minutes following romifidine sedation. The induction time, duration and recovery time were 9.20±0.27, 78.50±4.47 and 101.67±2.58 minutes respectively in group-I, 7.83±0.34, 91.00±1.96 and 116.33±3.37 minutes respectively in group-II and 4.98±0.29, 101.50±1.58 and 126.17±3.21 minutes respectively in group-III. In group-IV, atipamezole reversed romifidine sedation in 1.07±0.38 minutes. Induction and recovery were smooth. Muscle relaxation and analgesia were good. Animals of all group exhibited signs of sedation with lowering of head, occasional bellowing, heavy upper eyelid (drowsiness), onset of salivation, reduced tail movement and signs of staggering. Polyurea was observed at recovery. Heart rate decreased significantly (P<0.05) in group-I, II and III. Respiration decreased significantly (P<0.05) and rectal temperature decreased non-significantly (P>0.05) in all the three groups. Respiratory tidal volume and Respiratory minute volume decreased significantly (P<0.05) in the group-I, II and III. MAP also decreased significantly (P<0.05) and SpO2 decreased non-significantly (P>0.05) in the group-I, II and III. Hb, PCV, TEC and ESR also decreased non-significantly (P>0.05) in group-I, II and III. Highly significant (P<0.01) increased of GGT in group-I, II and III and glucose, BUN and creatinine increased significantly (P<0.05) in all these three groups. Total protein decreased non-significantly (P>0.05) in group-I and II and decreased significantly (P<0.05) in group-III. Cortisol increased significantly (P<0.05) in all the four groups. Atipamezole effectively reversed the effects of romifidine and the values returned towards the pre-administration level within 15 minutes. Based on the findings of the study, romifidine –ketamine anaesthesia and its reversal by atipamezole can be suggested for use in clinically affected bovine calves.