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Subject: Veterinary Surgery and Radiology × Author: SAIKIA, ANANGSHA × End date: 2017 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    ROMIFIDINE AND ITS COMBINATION WITH KETAMINE IN DOG
    (Assam Agricultural University, Khanapara, Guwahati, 2016-07) SAIKIA, ANANGSHA; Sarma, B.
    Fifteen clinically affected dogs of either sex and different age groups were divided into three groups consisting of five dogs in each. Intramuscular injection of romifidine @ 40 µg/kg b. wt. was injected to group I; romifidine @ 30 µg/kg b. wt. and ketamine @ 5 mg/kg b. wt. to group II and romifidine @ 40 µg/kg b. wt. along with ketamine @ 5mg/kg b. wt. to group III. The induction time of 12.80 ± 0.80, 8.40 ± 0.24 and 5.80 ± 0.37 mins; duration of anaesthesia of 50.20 ± 1.11, 64.40 ±0.81 and 76.20 ± 0.96 mins and recovery time of 69.40 ± 2.29, 86.40 ± 0.74 and 94.40 ± 0.67 mins were recorded in group I, II and III. Complete analgesia was present in group III. All the animals exhibited muscle relaxation, cessation of tail movement and salivation. Smooth induction and recovery were recorded in all the groups. In dogs of all the groups heart rate, respiration rate, rectal temperature, tidal volume, minute volume and oxygen saturation decreased significantly (p < 0.05). Mean arterial pressure increased significantly (p < 0.05) in all three groups. Haemoglobin and total erythrocyte count decreased significantly (p < 0.05) in all the groups. Non-significant (p > 0.05) reduction of packed cell volume was recorded in group I while significant (p < 0.05) decreased level was recorded in group II and III. Total protein decreased non-significantly (p>0.05) in group I but significant (p<0.05) decrease of total protein was recorded in other two groups. GGT, blood glucose, alkaline phosphatase, BUN, creatinine and cortisol increased significantly (p<0.05) in all the groups. Based on the observation, romifidine @ 40 g/kg b. wt. and ketamine @ 5 mg/kg b. wt. could be recommended for surgical procedures. Romifidine @ 30 g/kg b. wt. and ketamine @ 5mg/kg b. wt. is suggestive for minor surgical procedure while romifidine @ 40g /kg b. wt. is not recommended for clinical use.