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20131
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Subject: Veterinary Surgery and Radiology × Author: DEURI, BITUPONA × End date: 2017 × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    INTEGRATED SURGICO-THERAPEUTIC MANAGEMENT OF CANINE MAMMARY TUMOUR
    (Assam Agricultural University, Khanapara, Guwahati, 2013-07) DEURI, BITUPONA; Sarma, K. K.
    The present study was conducted on clinical canine patients presented to the College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati-22 for five calendar years starting from 1st April 2008 to 31st March 2013. Of the total 5760 cases registered, 330 were various neoplasm cases and 114 (34.55%) were confirmed as mammary gland tumours. Incidence study revealed that the age groups between 9-12 years (41.23%) were mostly affected and German Spitz (49.09%) breed and females (97%) were more susceptible and the inguinal pair (68.42%) of gland was mostly affected. Among 53% malignant and 47% benign tumours, papillary adenocarcinoma and fibroadenoma (24.57%) were highest. Clinical study revealed that the intact bitches were mostly affected and were also associated with other diseases like pyometra etc. The mammary tumour cases were further divided into three groups having six animals in each group. The animals of Gr-I were treated with regional mastectomy alone, Gr-II with chemotherapy (Capecitabine ‘Xabine’500mg oral tablets) and that of Gr-III were treated with mastectomy followed by the use of capacitabine. In GR-I, after regional mastectomy, the benign tumours didn’t show and reoccurrence where as two malignant tumours reoccurred after 1 year. In GR-II, after capecitabine therapy, the tumour less than 3cm size regressed after second round of chemotherapy but the tumours above 3cm size didn’t show any regression. In GR-III, there was no incidence of recurrence till one and half year of treatment. The hematological parameters revealed no adverse effects on the animal’s health except mild leucopaenia, neutropenia, thrombocytopaenia, lymphocytosis and monocytosis for a transient time in GR-II and GR-III as a result of chemotherapy. Whereas, the biochemical parameters revealed significant difference in BUN, Serum creatinine, AST, ALT and ALP levels within groups as well as between groups. But the effects were not long lasting to hamper the animal’s general health. The estradiol, progesterone and cortisol levels were significantly higher in mammary tumour cases which subsided in due course of treatment. Complications were minimal except mild anorexia and discharges from the tumour site.