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Subject: Clinical Veterinary Medicine, Ethics and Jurisprudence × Author: HUSSAIN, JAKIR × Start date: 2019 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON ANTHELMINTIC EFFICACY OF Zanthoxylum armatum AGAINST GASTROINTESTINAL PARASITES OF GOAT
    (College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, 2022-01) HUSSAIN, JAKIR; Dutta, T. C.
    The present investigation was carried out to study the anthelmintic efficacy of hydroethanolic seed extract of Zanthoxylum armatum against gastrointestinal parasites of goats. The overall prevalence of gastrointestinal parasites in goats was recorded to be 65.41% under prevailing agro-climatic conditions of Goat Research Station, AAU, Burnihat and private farms in and around Guwahati city, Assam from January- March 2021 & September - November 2021.Out of the different gastrointestinal parasites recorded in goats the prevalence of Haemonchus spp. (54.14%) was found to be the highest and Trichostrongylus spp. (18.78%) the lowest. In most of the animals, mixed infestations with 2-3 types of gastrointestinal parasites were also recorded. Phytochemical analysis of hydroethanolic seed extract of Zanthoxylum armatum revealed the presence of alkaloid, terpenoid, diterpene, flavonoid, steroid, glycosides, saponin and phenolic compounds but it was found negative for tannin. The acute oral toxicity study in mice showed that the hydroethanolic seed extract of Zanthoxylum armatum is safe up to 2000 mg/kg body weight when administered orally. In-vitro study of hydroethanolic seed extract of Zanthoxylum armatum showed dose-dependent and time-dependent anthelmintic activity and the highest efficacy was observed at 1000 μg/ml against adult parasite of Haemonchus contortus at 60 minutes. Based on the reduction of EPG count in the present study, Group A, animals which were treated with hydroethanolic seed extract of Zanthoxylum armatum @250 mg/kg body weight, orally and repeated on the 21st day showed the highest efficacy on post-treatment days i.e. 100% on the 28th day followed by the animals in Group C, treated with hydroethanolic seed extract of Zanthoxylum armatum @125 mg/kg body weight and ethanolic seed extract of Butea frondosa @ 50 mg/kg body weight, Group B,treated with hydroethanolic seed extract of Zanthoxylum armatum @125 mg/kg body weight and methanolic seed extract of Entada phaseoloides @250 mg/kg body weight and Group D, treated with hydroethanolic seed extract of Zanthoxylum armatum @125 mg/kg body weight, methanolic plant extract of Entada phaseoloides @250 mg/kg body weight and ethanolic seed extract of Butea frondosa @50mg/kg body weight, orally and repeated on 21st day. The In-vivo study showed that the hydroethanolic seed extract of Zanthoxylum armatum individually or in combination with methanolic seed extract of Entada phaseoloides and ethanolic seed extract of Butea frondosa were effective against gastrointestinal parasites of goats. Based on the improvement in body weight and haemato-biochemical parameters with reduction of EPG of faeces it was observed that hydroethanolic seed extract of Zanthoxylum armatum was more effective as anthelmintic when used alone than in combination against gastrointestinal parasites of goats.