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Subject: Veterinary and Animal Science × Author: Arivuchelvan, A × Author: KAU × End date: 1997 × Start date: 1992 ×
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    ThesisItemOpen Access
    Anti-inflammatory and antinociceptive effects of Withania somnifera and Catharanthus roseus in rats
    (Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, 1997) Arivuchelvan, A; KAU; Joy, A D
    The present study was undertaken with the objective of determining the anti-inflammatory and antinociceptive effects of withania somnifera and Catharanthus roseus. Alcoholic extract of both the plants were used for the study and the effect produced by the above plants were compared with that of the known non-steroidal anti-inflammatory drug namely, diclofenac sodium which served as the positive control drug. To assess the anti-inflammatory effect two methods namely, cotton pellet and carrageenin induced paw oedema were adopted. In cotton pellet method five groups of eight rats each were used per plant. First group was kept as a control, which received five per cent gum acacia only. IInd, IIIrd and IVth group received 200, 400, 600 mg/kg alcoholic extract of C. roseus Vth group served as the positive control which received diclofenac sodium 3 mg/kg dose level. All the drugs were administered orally. C. roseus produced significant anti granuloma activity when compared to control group. Higher activity was produced by 600 mg/kg body weight extract (35.88 per cent anti-inflammatory activity). For W. somnifera also same experimental design was adopted with dose rates of 750, 1000, 1500 mg/kg body weight. W. somnifera produced dose dependent antigranuloma activity. Higher dose (1500 mg/kg body weight) produced more antigranuloma activity (53.92 per cent) which was comparable to the antigranuloma activity of diclofenac sodium. Haematological parameters before and after treatment showed no significant changes for both the plants. In carrageenin induced paw oedema method al so five groups of eight rats each were used per plant. All the three doses of extract and reference drug were given thirty minutes prior to the carrageenin injection and the paw thickness was recorded three hour after injection. c. roseus produced significant antioedema activity in this model. Higher dose (600 mg/kg) produced equipotent effect compared to diclofenac sodium 3 mg/kg. W. somnifera also produced dose dependent anti oedema activity. Extract at the dose rate of 750, 1000, 1500 mg/kg produced 19.4, 35.23, 44.62 per cent antioedema activity respectively. But the reference drug diclofenac sodium produced higher antioedema activity. For evaluating antinociceptive effect of C. roseus and W. somnifera, seven groups of eight animal each were used. All the dose rates of both the plant extracts were compared with diclofenac sodium for a period of two hours showed no significant analgesic effect.