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20101
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Subject: Veterinary Surgery and Radiology × Author: Chinchu, Jose × Start date: 2000 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    Efficacy of collagen sheet for the management of corneal ulcers in dogs
    (College of Veterinary and Animal Sciences, Mannuthy, 2010) Chinchu, Jose; KAU; Anoop, S
    The efficacy of collagen sheet of bovine intestinal origin in the healing of corneal ulcers were studied in six dogs and were compared with the healing without the use of it in another six dogs. Dogs presented with corneal ulcers and/or with staphylomas were clinically examined and selected for the study. Surgical manipulations were performed under general anaesthesia. In Group I, collagen sheet was placed after scarification and/or superficial keratectomy and in Group II, scarification and keratectomy was performed. Temporary tarsorrhaphy was done in all dogs. Oral administration of cephalexin was maintained in all the cases. Ocular instillation of ciprofloxacin as primary antibiotic or based on the culture sensitivity test and flurbiprofen were administered till the complete healing. Elevated intraocular pressure was controlled by acetazolamide orally and by timolol maleate or dorzolamide topically.Collagen sheets of intestinal origin were completely dissolved by 3rd day and no remnants were seen. It was well tolerated by the dogs and no immune reactions were noticed. Since the collagen sheet was very pliable after soaking with gentamicin eye drops, it could be applied over the cornea very easily without any air spaces and retained in position by temporary tarsorrhaphy. Fluorescein dye test became negative by 7th day in most dogs treated with collagen sheet and complete epithelization of the corneal defects was occurred by the time. Whereas the fluorescein dye retention was positive till 14th day in most dogs in Group II. Corneal vascularization developed in all the cases were resolved by the end of the observation period. Complete reconstruction of the cornea was seen early in staphyloma cases under the collagen sheet treatment in Group I. But the clarity of the cornea was unable to regain within the observation period of the study in most cases. In stromal ulcers, the clarity was achieved by 60th day. The presence of anterior synechia was responsible for the delayed corneal clearing most of the staphyloma cases. Corneal pigmentation was the major complication encountered in either modality of treatment under this study.