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Subject: Veterinary Medicine × Author: Jessy, V × End date: 2010 × Start date: 2006 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    Evaluation of haemato-biochemical changes associated with ciprofloxacin therapy in canine pyoderma
    (Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Mannuthy, 2008) Jessy, V; KAU; Jayavardhanan, K K
    The present study was undertaken with the objective to assess the haemato-biochemical changes following prolonged ciprofloxacin therapy in dogs affected with pyoderma. The study was conducted in dogs presented to the Veterinary College Hospital, Mannuthy, during the period from August 2007 to March 2008. Among the twenty one dogs studied, twelve completed the full course of antibiotic therapy and post treatment evaluation. The pyoderma confirmed dogs were treated with ciprofloxacin @ 10 mg/kg body weight once daily orally for a period of 14 days. Blood samples collected on day 0, 7 and 14 of treatment and fifth day after the completion of therapy was subjected to haemato-biochemical analysis. Signalment indicated an age wise occurrence of pyoderma and was highest in one to three years of age group (38.10 %). Breed wise occurrence was highest in GSD (38.10 %) and sex wise prevalence was higher in males (52.38 %). Clinical signs and lesions noted in the 21 dogs were combinations of papules and pustules, matting of hairs, erosions, cellulitis, alopecia, scales, hyperpigmentation and pruritus. The antibiotic sensitivity pattern of the gram positive cocci isolates from skin swabs showed maximum sensitivity to ciprofloxacin followed by cefotaxime, cephalexin, gentamicin and amoxycillin. Haematological examination of the blood samples showed no change in TEC, Hb, PCV, ESR and DLC (moncyte and eosinophil) between before, during and after treatment. But a significant variation in TLC, neutrophil and lymphocyte were noticed in dogs with pyoderma. As the treatment progressed, the condition of the animal improved which resulted in decreasing TLC and neutrophil count to normal level. The data obtained on hepatocellular enzymes ALT, AST and other biochemical parameters such as total protein, albumin, A:G and cholesterol suggest that treatment with ciprofloxacin might not have produced any adverse effect on liver tissue. Serum BUN and creatinine levels were found within the normal range. The electrolytes, sodium and potassium were also not altered during the course of treatment. These observations suggest that prolonged administration of ciprofloxacin, at the dose rate mentioned, is not capable of causing any nephrotoxicity. Reduced glutathione also support the above conclusion by eliminating the chance of having any oxidative stress. The present study conclude with the findings that prolonged ciprofloxacin treatment does not produce any deterioration in hepatic and renal system of dogs affected with pyoderma, suggesting ciprofloxacin treatment as a safe and efficacious drug for the complete cure of canine pyoderma.