Thumbnail Image

Theses

Browse

1998 - 199922000 - 20031
Reset filters
Subject: Others × Start date: 1998 × Thesis Type: M.V.Sc. ×
Reset filters

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    ThesisItemOpen Access
    Effect of depuration on the meat quality of the marine clam Sunetta scripta (Linne)
    (Department of Processing Technology, College of Fisheries,Panangad, 1998) Nishi Dharan, S; Damodaran Nambudiri, D
    Sunetta Scripta harvested from Munabam area were subjected to depuration studies to find out whether purging had any effect on the meat quality of the clam. Result of biochemical analysis shows that the clam is a good source of various nutrients. Meat yield of clam was found to be 9.5%. Pathogenic bacteria was absent except E. coli ,. which is within the permissible limits. Depuration of clam did not significantly change the protein and glycogen content. But sand content was reduced to insignificant level within 24 hr depuration. When clams were exposed to a concentration of 109 ceUS/ml of Vibrio parahaemolyticus, there was progressive accumulation of the micro-organism and it accumulated on an average of 2.6xl05 cells/g within 6 hrs exposure. Though accumulated organism was not completely eliminated from the clams during purification in a laboratory depuration unit using U. V for sterilising the water, the number had reduced to more than 1000 fold during 48 hrs depuration. There was remarkable change in the sensory attributes and grittiness character of the clam after depuration
  • Thumbnail Image
    ThesisItemOpen Access
    Nephroprotective effect of Aerva Lanata (Cherula) and Boerrhavia Diffusa (* Thazhuthama) in rats
    (Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences,mannuthy, 2003) Fakrudeen Ali Ahamed, N; Venugopalan, K
    An experiment was conducted to assess the nephroprotective effect of Aerva lanata (Cherula) and Boerrhavia diffusa (Thazhuthama) against gentamicin induced nephrotoxicity in rats. A group of 48 adult albino rats weighing 150-250 g of either sex were include in six groups and each group consisting of eight rats. All the experimental groups except. saline control (G I) were given gentamicin sulphate (80 mglkg/day subcutaneously) for 12 days. After 12 days, the experimental groups (G3, G4, G5 and G6) were given two selected doses [(G3 and G5 - 250 rng/kgjand (G4 and G6 - 500 mg/kg)] of dried alcoholic extract of Aerva lanata and Boerrhavia difJusa orally, for a period of another 21 days respectively. Feed intake and body weight was reduced in gentamicin administered groups (G2, G3, G4, G5 and G6) at I ih day and it was reverted to normal at 33rd day (G3, G4, G5 and G6). . Elevated blood urea nitrogen (1 ih day) was reverted to normal at 26th day in Aerva lanata @ 250 and -500 mg/kg (G3 and G4) and at 33rd day in Boerrhavia diffusa @ 250 and 500 mg/kg (G5 and G6) respectively. Microscopical examination of urine at 33rd day, revealed the initiation of regeneration of renal epithelium. The severity of gross and microscopical lesions of kidney observed at 12th day was minimized at 33rd day, indicate the nephroprotective effect of Aerva lanata and Boerrhavia diffusa. The change in haemogram at I z" day (reduced total leukocyte count, neutrophil count and increased Iymphocyte count) was reverted to normal in all the groups at 33rd day. Hence the study confirmed that Aerva lanata and Boerrhavia diffusa posses nephroprotective action and it could be used as nephroprotective agents .
  • Thumbnail Image
    ThesisItemOpen Access
    Anti-ulcer activity of Ocimum sanctum (Thuiasi ) Musa (AAb Group,Nendran) and Withania somnifera(Amukkiram) in rats
    (Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences,mannuthy, 1998) Sanjay, D; KAU; Venugopalan, K
    The study was~conducted in adult albino rats of either sex to assess the comparative anti-ulcer effect of powder and alcoholic extract of Ocimum sanctum (leaves), Musa (AAB group, "Nendran", mature, unripe fruit) and Withania somnifera (root) with Famotidine, at different dose levels given orally for 10 days and, 20 days after induction of gastric ulcers with aspririn at the dose rate of 200 mg/kg body weight for 7 days orally. The doses of different plant preparation were fixed arbitarily (Table 1) . Table 1. Doses of oc imum sanct um leaves, Musa (AAB group •. Nendran" ) mature and unripe fruit, withania somnifera root and Famotidine (in mg/kg orally) were fixed as below Plants Alcoholic extracts 10 dayo treatment 20 days treatment Powder 10 days treatment . 20 days treatment Ocimum sanctum G( 1) G(2) G(3) G(4 ) G(5) G(6) G(7) G(8) 250 500 250 500 500 1000 500 1000 Nusa (MS group G(9) 0(10) G( 11) (3(12) G( 13) G( 14) G(15) G( 16) Nendran) 500 1000 500 1000 1000 2000 1000 2000 Withania G(l7 ) G(18) G( 19) G(20) G(21) G(22) G(23) G(24 ) somnifera 250 500 250 500 500 1000 500 1000 Famotidine 10 days treatment F(10) 20 days treatment F(20) 40 mg/kg p.o 40 mg/kg p.o Control group A (CG(A) I - Aspirin treated controls (200 mg/kg b.wt) Control group B (CG(B) I - Natural healing for 10 days Control group C (CG(C) I - Natural healing for 20 days Control group A [CG(A)] was given aspirin at the dose rate of 200 mg/kg body weight for 7 days and on the 8th day, the rats were sacrificed and number of ulcers and severity (ulcer score) were determined with the help of magnifying lens. 11 The ulcer index and healing index were calculated based on the formulae: Ulcer index = Number of ulcers + Ulcer + score % incidence Number of animal Ulcer index (control) CG(A) Healing index Ulcer index (control) CG(A) Ulcer index (drug) x 100 The control group B [CG(B)] and control group C [CG(C)] were administered aspirin orally for 7 days and they were maintained by normal feeding and watering without any treatment for 10 days and 20 days respectively to assess natural healing. Famotidine was taken as standard drug and given orally at the dose rate of 40 mg/kg body weight for 10 days and 20 days respectively. The anti-ulcer activity of plants under study was compared with Famotidine . . Haematological parameters such a erythrocyte count, total leukocyte count, differential count and haemoglobin count were decermined to assess any changes in the haemogram. Histopathological study was also conducted to evaluate the severity of ulceration and healing process. The result of the present study with O. sanctum leaf powder and alcoholic extract showed that none of the experimental groups produced statistically significant healing effects comparable to Famotidine groups. Observation with Musa (AAB group, "Nendran") unripe fruit powder and alcoholic extract have indicated that all experimental group under study with the plant have better healing effect than control group for 10 days. The alcoholic extract of Musa (AAB group, "Nendran") at the dose rate of 1000 mg/kg body weight for 10 days, 500 mg/kg body weight for 20 days and 1000 mg/kg body weight for 20 days produced healing comparable to Famotidine at the dose rate of 40 mg/kg body weight for 10 days and 20 days respectively. The result of healing obtained with W. somnifera root indicate that alcoholic extracts at the dose rate of 250 mg/kg body weight for 20 days and 500 mg/kg body weight for 20 days and powder at the dose rate of 1000 mg/kg body weight for 20 days are comparable with Famotidine groups administered for 10 days and 20 days respectively. All other experimental group under study with this plant produced healing comparable to Famotidine administered for 10 days. Haematological study revealed no significant change and all values fall within the normal range of blood value for the species under study. Histopathological study revealed various ulcer lesions and healing process.