Thumbnail Image

Theses

Browse

2005 - 20094
Reset filters
Subject: Clinical Veterinary Medicine, Ethics and Jurisprudence × End date: 2009 × Start date: 2004 ×
Reset filters

Search Results

Now showing 1 - 4 of 4
  • Thumbnail Image
    ThesisItemOpen Access
    Clinical and ultrasonographic investigations of ascites in dogs
    (Department of Clinical Medicine, College of Veterinary and Animal Sciences,Mannuthy, 2005) Jegaveera Pandian, S; KAU; Usha Narayana, Usha Narayana
    Study entitled “Clinical and Ultrasonographic Investigation of Ascites in Dogs” was conducted in ten dogs. The study aimed at understanding the etiopathogenesis of ascites in dogs. The parameters observed were signalment, history and detailed clinical examination, electrocardiography, ultrasonography of liver, kidney and heart, course of illness, estimation of haemoglobin concentration packed cell volume(PCV), total plasma protein, albumin, A: G ratio, liver enzymes like alanine amino transferase (ALT) and alkaline phosphatase (ALP), protein content in ascitic fluid , ascitic fluid to plasma protein ratio, blood urea nitrogen (BUN), serum creatinine, sodium and potassium. Inappetance and lethargy were observed in dogs with liver diseases. Cardiac palpitation, loud heart sounds and strong femoral pulse were noticed in dogs with CHF. Non- specific and vague signs were noticed in dogs with nephrotic syndrome. Deep ‘Q’ waves in leads I, II and aVF, prolonged ‘QRS’ duration, S-T slurring, tall ‘R’ waves, mild sinus arrhythmia and S1, S2 and S3 pattern were the abnormal ECG findings in dogs with CHF. No marked changes could be observed in the ECG of dogs with ascites of hepatic and renal origin. Ultrasonography of liver revealed hyperechogenicity of parenchyma, specks of hyperechogenicity and mildly echogenic gall bladder contents in three out of five dogs with ascites of hepatic origin. Two dogs had uneven and eroded borders along with hyperechoic liver parenchyma in dogs with ascites of hepatic origin. Nephrosonogram was unremarkable in all the ten dogs. Ultrasonographic findings and serum biochemical findings were coinciding with each other. Ultrasonography was an efficient tool in studying the changes of liver parenchyma and portal vasculature. ECG in cardiac diseases was complementary to echocardiography. Echocardiography was efficient in diagnosing DCM (two dogs) and HCM (one dog). All the dogs with liver diseases had mild to marked elevation in serum levels of ALT and/ or ALP. Hypoproteinemia and hypoalbuminemia were observed in dogs with liver and kidney diseases. Liver and kidney function tests were unremarkable in dogs with nephrotic syndrome and heart diseases. Treatment regimen involved administration of furosemide and/ or furosemide + spironolactone, silymarin, Liv- 52 Vet, enalapril, digoxin and prednisolone as the case may be. Six out of 10 dogs survived beyond 30 days following the therapy instituted. Nephrotic syndrome in dogs could be concluded by progressing hypoproteinemia especially hypoalbuminemia, low- protein ascites, negative ECG and echocardiographic findings and non- responsiveness to therapy. Nephrotic syndrome can be confirmed by biopsy and / or urine protein: creatinine ratio. Liver diseases can be confirmed and characterized only with biopsy.
  • Thumbnail Image
    ThesisItemOpen Access
    Thyroid function evaluation in canine dermatoses
    (Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2005) Renju, Alias; KAU; Jayakumar, K M
    Prevalence of hypothyroidism was studied among the dogs presented with dermatological problems at the University Veterinary Hospitals, Mannuthy and Kokkalai, during the period from June 2004 to May 2005. Among 1,233 dermatological cases presented, hypothyroidism accounted for 1.23 per cent (16 cases) Dogs between the age group of seven to ten years were more frequently affected and no significant differences in the incidence rate between male and female dogs were observed. Hypothyroidism was recorded more in German Shepherd breed followed by Dachshunds. Low serum thyroxine (T4) and high thyroid stimulating hormone (TSH) level with normal or low normal T3 levels were observed in the hypothyroid dogs. The most common dermatological changes exhibited by hypothyroid dogs included seborrhea, alopecia of tail and around the neck, bilaterally symmetrical pattern of hair loss and coat changes such as dryness, dullness, dandruff, scaliness, coarseness and sparseness. A significant increase in serum cholesterol concentration was observed in the affected dogs. Serum enzymes such as alkaline phosphatase and gamma glutamyl transferase were showed elevation in few cases. Replacement therapy using Eltroxin was found to be effective in treating hypothyroidism. A minimum of one month was needed to evaluate the therapeutic response. Four out of six (66.66 per cent) confirmed cases of hypothyroidism showed an excellent response to replacement therapy.
  • Thumbnail Image
    ThesisItemOpen Access
    Clinico-biochemical and ultrasonographic evaluation of renal failure in dogs
    (Department of Clinical Veterinary Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2009) Kanaran, P P; KAU; Alex, P C
    The study on “clinico-biochemical and ultrasonographic evaluation of renal failure in dogs” was conducted on 23 dogs. The parameters studied were signalment, history and clinical signs, physical examination findings, ultrasonography of the kidney, haematology, serum biochemistry and urinalysis, urine protein creatinine ratio, urinary enzymes as markers of renal disease, response to treatment, peritoneal dialysis as a treatment option and postmortem examination and histopathology. All the renal failure cases studied were associated with nephrotoxic drugs, microfilariosis, pyometra, prostatic enlargement, pancreatitis, rhabdomyolysis or leptospirosis. The cases were divided into renal failure following exposure to nephrotoxic drugs, microfilariosis, pyometra, prostatic enlargement, pancreatitis, rhabdomyolysis or leptospirosis. The haematological and biochemical values of the diseased animals varied from that of normal animals and did not show any significant difference with the values measured after seven days of treatment indicating that it was not effective. The most common ultrasonographic pattern was hyperechoic kidneys with lack of corticomedullary distinction indicating fibrotic changes in kidney which was confirmed by postmortem examination and histopathology. Estimation of urinary enzymes NAG, GGT and ALP were done in selected animals. There was a sharp difference between diseased and healthy animals. It was concluded from this study that for effective treatment and management of canine renal diseases, early diagnosis and treatment is a must and that for achieving this goal ultrasonography and estimation of urinary enzymes can be used as effective tools.
  • Thumbnail Image
    ThesisItemOpen Access
    Investigaion on hepato-biliary disorders in dogs
    (Department of Clinical Veterinary Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2008) Elso, John; KAU; Jayakumar, K M
    Investigation on heapto-biliary disorders was conducted in forty dogs using ultrasonography and correlated ultrasonography with haemato-biochemical and histological findings. Parameters studied were history, clinical signs, physical examination, ultrasonography of liver, serology, haematology and serum biochemistry, post-mortem examination and histopathology. Age of affected animals with hepato-biliary disorders was 4.54 ± 0.47 years. Among dog breeds, highest incidence was found in German shepherd followed by Dachshund. Female dogs were more affected by the hepato-biliary disorders. Clinical signs more specific to hepato-biliary disorders were ascites and icterus. Primary hepatic diseases that produced ultrasound changes were hepatic abscess, hepatic neoplasia, leptospirosis, cirrhosis, fibrosis and chronic active hepatitis. Biliary changes were observed in cholangiocellular carcinoma, chloangiohepatitis, cholecystitis, cholelithiasis and gall bladder sludge. Secondary liver diseases were associated with pyometra, ehrlichiosis, rhabdomyolysis and passive venous congestion due to dilated cardiomyopathy. Varying degrees of leucocytosis and anaemia were the consistent finding. Total serum protein and albumin were reduced in majority of hepato-biliary disorders, with a marked reduction in cirrhosis and fibrosis. Serum copper level was elevated in Dalmatians with chronic hepatitis. Serum alpha feto protein was detected/increased in hepatic neoplasia. Serum activities of alkaline phosphatase, alanine aminotransferase and gamma glutamyl transferase were elevated in varying degrees in majority of hepatobiliary disorders. Histological changes in leptospirosis were chronic venous and sinusoidal congestion. In cirrhosis, major histological findings were fibrosis and pseudolobulation whereas biliary hyperplasia in cholangiocarcinoma. From the present study it was inferred that ultrasonography was a valuable diagnostic tool for hepatopathies supported with clinico-haemato-biochemical findings.