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Physicochemical alterations in blood, cerebrospinal fluid and urine in experimental lactic acidosis in sheep
(1993) Patra, R.C
Ruminal acidosis was induced in six adult sheep . by oral feeding of wheat grain at 90 g kg-l body- ~ weight. Ruminal fluid, blood, cerebrospinal fluid -- . (CSF)andurinesampleswerecollectedbeforegrain feeding (0 h) and thereafter at 12, 24, 48, 72, 96 ~ and 120 hour intervals. Decrease in the rumen pH was associated with decreased pH in blood, CSF and urine and increased total lactic acid concentrations in rumen liquor, blood, CSF and urine. Significantly (P<0.05) increased levels of sodium, inorganic phosphorus and decreased levels of potassium and calcium were observed in the serum of acidotic sheep. CSF analysis revealed decreased potassium and chloride levelsand increased glucose concentration and total leucocyte count within' 12 hours of the grain feeding. Pandy's test was positive in half of the surviving sheep at 12 hours and in all the sheep at 96 and 120 hours of observation. In urine, sodium and chloride levels decreased while potassium and inorganic phosphorus increased. The, changes in the biochemical parameters started within 12 hours and lasted up to 48 to 120 hours of t the observation period.