Browsing by Author "Mathuram, L.N."
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ThesisItem Open Access Anti-Inflammatory Activity of Cassia Fistula in Sub-Acute Models of Inflammation in Rats(TANUVAS, 2005) Rajeswari, R.; TANUVAS; Thejomoorthy, P.; Mathuram, L.N.; Suresh, R.V.OtherItem Open Access Anti-Inflammatory and Antioxidant Activities of Leucas Aspera in Rats(TANUVAS, 2010) Kumar, R. Kishor; Thejomoorthy, P; Mathuram, L.N.OtherItem Open Access Antibacterial Activity of Cassia Fistula Extract on Pathogenic Bacteria of Veterinary Importance(TANUVAS, 2006-06) Vimalraj, T. Ranjith; Kumar, S. Saravana; Vadivel, S; Ramesh, S; Thejomoorthy, P; Mathuram, L.N.ThesisItem Open Access Antiinflammatory Effect of Vitex Negundo Linn in Rats(TANUVAS, 2004) Jaganathan, S.; TANUVAS; Kanniappan, M.; Mathuram, L.N.; Balachandran, C.OtherItem Open Access Antimutagenic and Anticlastogenic Effect of Tinospora Cordifolia(TANUVAS, 2006-06) Chandrasekaran, C.V.; Mathuram, L.N.; Sriram, PThesisItem Open Access Antimutagenic and Anticlastogenic Effects of Silymarin(TANUVAS, 2006) Kaleeswaran, S.; TANUVAS; Sriram, P.; Mathuram, L.N.; Leela, V.ThesisItem Open Access Cardioprotective and Anti-oxidant Effects of Tinospora Cordifolia in Myocardial Infarction Model in Rats(TANUVAS, 2006) Vineetha, C.B.; TANUVAS; Mathuram, L.N.; Ramesh, S.; Nagarajan, L.ThesisItem Open Access Dietary Manipulation Of Fat On Mitochondrial Decay And Its Implications On Ageing And Apoptosis(Tamil Nadu Veterinary and Animal Sciences University, 2009) David, Corbon Godfrey, I.; TANUVAS; Leela, V.; Thangavel, A.; Mathuram, L.N.; Vairamuthu, S.An investigation was carried out to study the effect of dietary manipulation of fat and calorie restriction (CR) on the production of ROS in relation to activity of mitochondrial electron transport complexes and its implications on apoptosis in ageing heart and brain. Eighteen months old male Wistar Albino rats were fed on coconut and corn oil based diets ad libitium or at 40 per cent CR up to 24 (short term) or 30 months (long term) of age. At the end of feeding trial rats were sacrificed. Mitochondria from heart and brain were isolated for the estimation of membrane fatty acid composition, H2O2 and OXPHOS enzyme activity. Mitochondrial inner membrane surface area was measured stereologically from electron micrographs. Antioxidant enzyme status, markers of oxidative stress measured as TBARS and protein carbonyls and DNA fragmentation were measured in both the tissues. Myocardial collagen and serum lipid profile were also estimated to correlate the effect of dietary fat and CR on retarding ageing. Both short and long term feeding of linoleic acid low coconut oil and linoleic acid rich corn oil based diets with CR increased oleic (18:1) linoleic acid (18:2) levels respectively in the heart and brain mitochondrial membranes. Reinforcement of 18:1 levels in membranes increased inner membrane surface area, membrane potential and reduced H2O2 production in rats fed on coconut oil based diet with CR compared to corn oil diet. The oxidative enzyme activities did not show appreciable age related variation in rats fed on coconut oil and corn oil based diets. Although, short term feeding of both coconut oil and corn oil based diets with CR effectively minimized age related changes in heart and brain, on the long run coconut oil based diet with CR was found effective to reduce oxidative damage to lipids and proteins but not DNA through enhanced antioxidant status. It is concluded that coconut oil based diets with CR reduces age related changes in heart and brain through reinforcement of membrane fatty acids, improved membrane integrity and decreased oxidative stress.ThesisItem Open Access Effect of Piperine on the Pharmacokinetic Profile of Ofloxacin in Chicken(TANUVAS, 2007) Parthiban, S.; TANUVAS; Ramesh, S.; Mathuram, L.N.; Kumarasamy, P.ThesisItem Open Access The Effect of Prostaglandin F2 Alpha and Norgestomet on Oestrus Responses and Embryo Production in Superovulated Cows(TANUVAS, 1997) Arosh, A. Joe; TANUVAS; Devanathan, T.G.; Rajasekaran, J; Mathuram, L.N.ThesisItem Open Access Experimental Induction of Myocardial Infarction and its Alleviation in Rats(TANUVAS, 2007) Gowda, C.J. Krishne; TANUVAS; Rao, G.V. Sudhakar; Manohar, B. Murali; Mathuram, L.N.ThesisItem Open Access Exploration of Anti-Inflammatory Activity of Curcuma Longa Extract Using In Vitro and In Vivo Methods(TANUVAS, 2009) Kavitha, N; TANUVAS; Mathuram, L.N.; Thejomoorthy, P; Tirumurugaan, K.G.ThesisItem Open Access Exploration of In Vitro and In Vivo Antimutagenic and Anticlastogenic Potentials of Boerhaavia Diffusa(TANUVAS, 2009) Ravichandra, B.V.; TANUVAS; Sriram, P; Mathuram, L.N.; Kumarasamy, PThesisItem Open Access Hepato and Renoprotective Effect of Terminalia Chebula and Andrographis Paniculata on Gentamicin Induced Toxicity(TANUVAS, 2008) Sivachandran, M.; TANUVAS; Hariharan, P.; Mathuram, L.N.; Srinivasan, S.R.OtherItem Open Access Histopathological Changes Induced by Experimental Per os Administration of Hexaconazole in Male and Female Reproductive Systems of Rats(TANUVAS, 2006-06) Kumar, P. Ravi; Kanniappan, M; Mathuram, L.N.; Manohar, B. MuraliThesisItem Open Access In Vitro Manipulation of Rumen Fermentation with Ionophores and Organic Acid(TANUVAS, 2003) Kumar, M. Bharath; TANUVAS; Sriram, P.; Mathuram, L.N.; Vijayarani, K.ThesisItem Open Access In Vitro Studies on the Antiproliferative Effect of Flavonoids on Sarcoma-180 Cell Line(TANUVAS, 2002) Raja, M.J.; TANUVAS; Mathuram, L.N.; Kanniappan, M; Sivaselvam, S.N.OtherItem Open Access Lupeol : A Plant Triterpene with Hepatoprotective Potential(TANUVAS, 2010) Preetha, S.P.; Venkateswaran, K.V.; Sriram, P; Mathuram, L.N.; Kanniappan, M; Baegan, S; Manohar, B. Murali