Browsing by Author "Basheer Ahamad, D"
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ArticleItem Open Access Evaluation of Hepatoprotective activity of Moringa oleifera in chicken(2020) Ranganathan, V; Punniamurthy, N; Basheer Ahamad, D; Sathesh Kumar, S; TANUVASThe present study was carried out to evaluate the hepatoprotective activity of Moringa oleifera on paracetamol induced hepatotoxicity in chicken. Twenty-four Giriraja birds were divided into four groups with six birds in each group. Birds in group I served as control and was administered with distilled water for 23 days continuously. Birds of group II were given paracetamol @ 2 g/kg body weight orally on day 17 and continued till the end of the experiment. Birds in group III were given silyamin @ 100mg/kg for 16 days and paracetamol was given from 17th day onwards @ 2 g/kg body weight along with silymarin till the end of the experiment. Birds in group IV were given shade dried powdered leaves of Moringa oleifera @ 1000 ppm in feed for 16 days and paracetamol was given from 17th day onwards @ 2 g/kg body weight along with medicinal plant till the end of the experiment. The biomarker enzymes such as alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase were tested and expression of mRNA levels of proinflammatory cytokines were screened for hepatoprotective activity of the plant. Histopathological observations were made with liver tissue for analysing hepatoprotective activity of the plant. Based on the results, the study suggests that Moringa oleifera has the potential to act as hepatoprotective agent.ArticleItem Open Access Pancreatic Exocrine Adenocarcinoma in a Cock(2018-04) Basheer Ahamad, D; Azmi, S; Balachandran, C; Sood, S; Nashirudullah, N; Badwal, MS; TANUVASPancreatic adenocarcinoma is a rare neoplasm of poultry. This condition is discussed in an adult cock that died suddenly in a flock of apparently healthy birds. Grossly, pancreas and mesentry of intestine, serosal layer of small intestine, gizzard, proventriculus, spleen, and liver showed grayish nodular growths on of various sizes. On histopathological examination, neoplastic cells arranged as tubular pattern of adenocarcinoma with transcoelomic metastasis to other organs. Based on pathomorphology, the growth was diagnosed as well differentiated pancreatic exocrine tubular adenocarcinoma in a cock.ArticleItem Open Access Pathology of Systemic Aspergillosis in a Desi Chicken(2018-04) Basheer Ahamad, D; Ranganathan, V; Punniyamurthy, N; Sivaseelan, S; Puvarajan, B; TANUVASSystemic aspergillosis in desi chicken was recorded. Clinically, 25% of birds showed anorexia, whitish droppings, dullness, depression and difficulty in respiration with 6% morality . Grossly, nodular swellings on subcutis near the right eye, head, neck and wings were seen. Cut section of those nodular growths revealed whitish grey cheesy contents. On internal examination, air sacs, lungs, proventriculus, kidney and abdominal wall revealed diffuse mild congestion, multi focal grayish foci of varying sizes. Histopathologically, mycotic granulomatous dermatitis, mycotic granulomatous pneumonia, mycotic air sacculitis, toxic hepatitis, lymphocytolysis in spleen, bursal atrophy, sub acute pericarditis, epicarditis and acute to subacute myocarditis were recorded. On histochemical examination, nodules in skin and lungs showed positive for fungus by Grocott - Gomori’s hexamine (Methenamine) silver staining. On fungal cultural examination, Aspergillus species was isolated from lungs and skin nodules. Based on pathomorphological, histochemical, fungal culture examination, the disease outbreak was diagnosed as aspergillosis in desi chicken farm.ArticleItem Open Access Toxic Effects of Citrinin in Animals and Poultry(2018-04) Basheer Ahamad, D; TANUVASCitrinin (CTN) is a secondary product of fungal metabolism, first isolated by Hetherington and Raistrick from a culture of Penicillium citrinum Thom (Hetherington and Raistrick, 1931). Meanwhile, several other fungal species within the three genera, Penicillium (P. expansum, P. verrucosum), Aspergillus (A. terreus), and Monascus (M. ruber) were also found to produce this mycotoxin (Ciegler et al., 1977, Bragulat et al., 1977). CTN contaminates maize (Nelson et al., 1985), wheat, rye, barley, oats (Scott et al.,1972), and rice (Tanaka et al., 2007). Citrinin was considered as a potential antibiotic (IARC, 1986), but its toxic properties prevented its therapeutic use. Citrinin (CTN), a low molecular weight compound, that melts at 172oC and is soluble in dilute sodium hydroxide, sodium carbonate, methanol, ethanol and other polar solvents (Leatherhead Food Research, 2000) was first isolated as a pure compound from a culture of Penicillium citrinum in 1931. Later, yellowish coloured rice imported from Thailand to Japan in 1951 was found to be contaminated with citrinin. Subsequently, it was identified in over a dozen species of Penicillium including certain strains of Penicillium camemberti (used to produce cheese) and several species of Aspergillus ( Aspergillus terreus, Aspergillus niveus) and Aspergillus oryzae, the latter being used to produce sake, miso, and soy sauce (Manabe, 2001).