STUDIES ON IMPLANTATION OF INTRAOCULAR LENS IN THE EYES AND OCULAR LENS MATERIAL IN THE MUSCLES OF RABBITS (Oryctolagus cuniculus)

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dc.contributor.advisorPATIL, D. B.
dc.contributor.authorRISHI, DEEPIKA DEV
dc.date.accessioned2018-06-11T08:04:26Z
dc.date.available2018-06-11T08:04:26Z
dc.date.issued2012
dc.description.abstractIntraocular lens (lOL) implantation after cataract operation has become widespread practice while its clinical results are generally satisfying. Despite this development, there still exist various problems in the design, materials and operative methods. Intraocular lenses are primarily located in the immediate vicinity of uveal tissue and are in direct contact with lens capsule tissue; this can cause a pathophysiologic reaction comprising inflammatory cells and lens epithelial cells. The reactive patterns of both types of tissue are generally considered indicators of lOL biocompatibility. The Polymethyl methacrylate (PMMA), Acrylic hydrophobic and Acrylic hydrophilic test implants were compared with the control implants in six healthy New Zealand White (NZW) rabbits. The ocular lens materials were implanted surgically into the body of paravertebral muscle. After the observation period of one month, the animals were sacrificed. The implant together with sufficient unaffected tissue was excised and subjected to histopathological evaluation. The PMMA IOLs were implanted in the eyes of the rabbit following lens extraction by extracapsular cataract extraction (ECCE) technique and the contralateral 6 right eyes were implanted with Acrylic hydrophilic foldable IOLs by Phacoemulsification technique. The rabbits were observed for a period of one month and the operated eyes were examined grossly and by slit lamp biomicroscopy. Grossly, tissue reactions like hematoma, edema, and encapsulation were not recorded at the paravertebral muscle implant sites. Histopathological examination of the implanted muscle sites arid the implant material revealed no vascularization, fatty infiltration, granuloma formation or inflammatory cells. All the PMMA and Acrylic hydrophilic foldable IOLs were successfiiUy implanted in the bag in the twelve eyes of six rabbits. Intraoperative complications observed were miosis and iris damage (1 eye). All rabbits were subjected to slit lamp examination. Post-operatively, slit lamp biomicroscopy revealed anteriorly dislocated lens (1 eye), neovascularization with corneal edema (1 eye), generalized corneal edema with AC flare and posterior synechiae (1 eye), Posterior capsular opacification, graded 1 (1 eye). Ophthalmic reflexes were present in 11 eyes and absent in 1 eye. Intraocular pressure (IOP) of the operated eyes was within the normal range of 18 to 22 mmHg for all the 11 eyes and buphthalmia with IOP 32 mmHg for 1 eye. Rabbits could successfully be used as models for the implantation studies of IOLs in the eyes following ECCE and phacoemulsification. Intramuscular biocompatibility testing of the ocular lens material in the paravertebral muscles of the rabbits bestowed the benefit of the test article being in a well-vascularized tissue, and this afforded the body the maximum opportunity to react with the test article.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810050838
dc.keywordsSTUDIES ON IMPLANTATION OF INTRAOCULAR LENS, THE EYES AND OCULAR LENS MATERIAL, THE MUSCLES OF RABBITS (Oryctolagus cuniculus)en_US
dc.language.isoenen_US
dc.publisherAAU, Ananden_US
dc.research.problemSTUDIES ON IMPLANTATION OF INTRAOCULAR LENS IN THE EYES AND OCULAR LENS MATERIAL IN THE MUSCLES OF RABBITS (Oryctolagus cuniculus)en_US
dc.subVeterinary Surgery and Radiologyen_US
dc.subjectVETERINARY SURGERY AND RADIOLOGYen_US
dc.subjectA STUDYen_US
dc.themeSTUDIES ON IMPLANTATION OF INTRAOCULAR LENS IN THE EYES AND OCULAR LENS MATERIAL IN THE MUSCLES OF RABBITS (Oryctolagus cuniculus)en_US
dc.these.typeM.V.Sc.en_US
dc.titleSTUDIES ON IMPLANTATION OF INTRAOCULAR LENS IN THE EYES AND OCULAR LENS MATERIAL IN THE MUSCLES OF RABBITS (Oryctolagus cuniculus)en_US
dc.typeThesisen_US
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