Sharma, R.J.Manirajan, P.2019-06-072019-06-072004-07http://krishikosh.egranth.ac.in/handle/1/5810107535In recent years, our vision is going to search for various naturally occurring compounds with antimicrobial activities because the development of resistance amongst the pathogens against so many synthetic antibiotics and fungicides. Many advocates claim that urine as a „panacea‟. Admiration of the cow‟s gentleness, products and power led the secular associations with the status of mother. Any place plastered by cow dung and any house sprinkled by cow urine are considered as sacred (or) pollution free. The ancient literature available in ayurveda is full of versions of utilization of cow urine as a potent medicine for various ailments of human beings and also it throws magnificent light on the importance of cow. The antimicrobial properties of cow urine were tested against the E. coli, Staph. aureus and S. enterica and found that the cow urine in pure form have comparatively more antimicrobial effect than in diluted form. In case of pharmacological properties of cow urine were tested in laboratory rats and Ascaridia galli (Poultry intestinal worms). The result on body weight gain weight gain of alloxan-induced diabetic rats showed higher weight gain when compared with other group of rats. Effect of cow urine on plasma glucose level of alloxan-induced diabetic rats showed no definite trend in reduction. The anthelminitc effect of cow urine and its extract on the spontaneous motility of Aseardia galli proved its anthelmintic properties. The cow urine and its extract reduced the blood pressure in rats. Finally, the cow urine extract showed increased amplitude and PR interval on ECG of rats with increased doses. The present studies showed that urine have both antimicrobial and pharmacological properties.ennullThesis