Madhanmohan, M.Kirubakaran, J. JohnRavimurugan, T.TANUVAS2022-01-062022-01-062021-01https://krishikosh.egranth.ac.in/handle/1/5810180455TNV_IJVASR_50(1)_Jan-Feb,2021_32-37Newcastle Disease (ND) is a highly infectious disease of poultry causing huge economic loss to the poultry farmers. Newcastle Disease is controlled by vaccination of commercial or backyard poultry using inactivated or live ND vaccines. In the present study, safety and humoral antibody response in birds vaccinated with Newcastle disease virus oral pellet vaccine (NDV OPV) was studied in field conditions. A total of 300 backyard poultry (n=100/ farm) from three different farms were vaccinated with NDV OPV. The vaccinated birds were monitored for any adverse reactions or mortality up to 28 days post vaccination (dpv). There were no untoward reactions or mortality in the vaccinated birds in all the three farms up to 28 dpv. Blood samples (n=8/farm) were collected randomly from vaccinated birds on 0 and 28 dpv in each farm and were subjected to heamagglutination inhibition (HI) test. The mean HI titre was 66, 56 and 25 in farm 1, farm 2 and farm 3 respectively at 28 dpv. All the vaccinated birds had protective HI titre of ≥16 at 28 days post vaccination. In conclusion, Newcastle disease virus oral pellet vaccine (NDV OPV) is safe and induces good protective humoral antibody response and can be used to control ND in backyard poultry.EnglishVeterinary ScienceVeterinary MicrobiologyArticle