Dr. Sakar PalechaRAJESH SAINI2018-06-132018-06-132017http://krishikosh.egranth.ac.in/handle/1/5810052398The present study was conducted on 20 dogs of both sexes with various surgical affections were randomly assigned to 2 anaesthetic induction groups (n=10) after premedication with glycopyrrolate (0.01 mg/kg; IM) followed by midazolam (0.25 mg/kg; IV) 15 min later. In group A, etomidate (1.46 mg/kg; IV) produced excellent to good induction with average score 3.80 ± 0.13. In group B, propofol (4.68 mg/kg; IV) produced good to excellent with average score 3.70±0.15. Induction with etomidate and propofol resulted in the alterations in various clinical, physiological and haemato-biochemical parameters observed in both group A and B. Rectal temperature showed significant decreasing trend just after induction, at 5 minute and 10 minute in group A and significantly decreased throughout the anaesthesia in group B from the base line value. Other parameters showed non-significant changes at different time intervals. Recovery was satisfactory in both the groups and was recorded faster (5.60±0.56 min) in group A as compared to group B (7.9±0.55 min). The quality of recovery had better score (3.80±0.13) in group A than group B (3.6±0.22) The average score for quality of ataxia recorded in group A was 3.6±0.22 compared to 3.1±0.23 in group B. Adverse signs reported during induction were pain on injection, myoclonus, hypersalivation, and transient apnoea and during recovery, excitement and paddling were observed. However, yawning was observed as a specific finding in all the animals of group A during induction of anaesthesia with etomidate. Overall observations showed that etomidate could be a satisfactory alternative to propofol in situations where short duration anaesthesia with minimal cardio-pulmonary depression is desirable.ennullThesis