Dr. N.C. BanerjeeBirendra Kumar Roy2024-06-062024-06-061991https://krishikosh.egranth.ac.in/handle/1/5810209694In order to achieve the objective of regulating optimization of CZ therapy in goats, a kinetic model of the drug has been constructed both in afebrile and febrile goats evincing a two compartmental open modal system'. Pharmacokinetic interaction of Probenecid with CPZ in the modulation of its kinetic behavior has also been identified. The kinetic appraisal of crz has revealed significant differences in several kinetic parameters between afebrile and febrile goats. The CPmax of CFZ in febrile goats (83.70+2.16ug/ml) was higher than in afebrile goats (67.71+1.44 ug/ml) after i.v. administration, on the contrary, after 1.m. administration the observations were reversed apparently due to concurrent differences in the values of related kinetic parameters such as Cla cla, Clu and Va Evidence has been presented that after CFZ-PB administration (1.v.) in febrile goats; the Cpax (170.00+2.33 ug/ml) of CFZ was significantly higher than that in febrile goats which received only CPZ (83.2042.16 ug/ml). Likewise, the duration of CP there was longer (3.50 h) in CPZ-PB recipient febrile goats ranging from 6.05+0.53 to 170.00 2.33 ug/ml) in contrast to other duration (45 min) ranging from 5.5040.23 to 83.20+2.16 ug/ml in febrile goats which only received CFZ. Evidence has been presented that the drug appearance time (lag) in milk of both afebrile and febrile goats after i.v. dose was 0.08 h (5 min).EnglishThesis