Kulkarni, HarishWilliam, JustinGeorge, Ravi SundarKannan, TATANUVAS2019-11-122019-11-122015-12http://krishikosh.egranth.ac.in/handle/1/5810135124TNV_IJVS_2015_36(2)82-87The objective of the study was to evaluate cardiopulmonary and haematobiochemical changes and stress response associated with administration of nalbuphine HCl during ketamine anaesthesia in horses premedicated with xylazine or xylazine-acepromazine. Eighteen clinical cases of horses brought for diagnostic and surgical procedures requiring general anaesthesia were randomly divided into three groups, I, II and III, each consisting of six animals. All the horses were premedicated with glycopyrrolate 0.02 mg/kg b.wt, i.v. Horses in group I and group II were administered xylazine HCl 1.10 mg/kg b.wt, i.v. In group III, 0.50 mg/kg b.wt xylazine HCl was administered i.v., followed by acepromazine 0.02 mg/kg b.wt, i.v. Before induction of anaesthesia, nalbuphine HCl was administered in group II and group III animals @ 0.75 mg/kg b.wt, i.v. Ketamine HCl was administered i.v. to induce anaesthesia @ 2.20 mg/kg b.wt and maintained with 0.50 mg/ kg b.wt in required cases for duration of 15±1.04 min. The heart rate increased during intraoperative period reached baseline value 6 hr after surgery. The respiratory rate and mean saturated partial pressure of oxygen decreased significantly during intraoperative period. Haemoglobin, PCV, TEC and TLC decreased significantly; the neutrophil and monocyte counts increased and the lymphocyte count decreased significantly during intraoperative and postoperative period in all the groups. The blood glucose, creatinine, plasma cortisol and plasma catalase activity significantly increased during intraoperative period and postoperative period. The total protein values significantly decreased during the intraoperative period in all the groups. To conclude, administration of nalbuphine HCl did not produce any marked changes in cardiopulmonary, haematobiochemical parameters and produced less stress response.enVeterinary ScienceArticle