Verma, M. P.BHAVSAR, S. K.2018-07-022018-07-022000http://krishikosh.egranth.ac.in/handle/1/5810056485The present study was conducted to determine the pharmacokinetics of ciprofloxacin after single dose intravenous, intramuscular or subcutaneous administration and multiple-dose intravenous administration. Additionally safety of multiple intravenous doses was evaluated. Following single dose (5 mg/kg of body weight) and multiple-dose (5 mg/kg of body weight repeated at twelve hour intervals for two and five days) intravenous administration of ciprofloxacin, the therapeutically effective serum ciprofloxacin concentration (> 0.12 µg.ml-1) was maintained for up to 8 hours. The pharmacokinetics of the drug was best described by two-compartment open model following the single and multiple-dose intravenous administration of ciprofloxacin. The drug was widely distributed (Vd area; 1.99 ± 0.07 1 kg-1) and rapidly eliminated (t1/2β; 1.69 ± 0.12 hours) following intravenous administration. The drug was not detectable 12 hours after the fourth or tenth intravenous doses given at the rate of 5 mg/kg of body weight in calves. Single and multiple-dose pharmacokinetics of the drug were found to be identical. Following single-dose administration at the rate of 5 mg/kg of body weight, therapeutically effective serum ciprofloxacin concentration was detectable at 2 minutes after intravenous and intramuscular administration and at 8 minutes after subcutaneous administration, However, the concentration was maintained for longer time after subcutaneous administration (12 hours) than following intramuscular administration (8 hours).enVETERINARY PHARMACOLOGYA STUDYThesis